DJ Taro

Kenichi and his detective uncle, Shunsaku Ban, leave Japan to visit Metropolis, in search of the criminal, Dr. Laughton. However, when they finally find Dr. Laughton, Kenichi and Shunsaku find themselves seperated and plunged into the middle of a larger conspiracy. While Shunsaku searches for his nephew and explanations, Kenichi tries to protect Tima (a mysterious young girl), from Duke Red and his adopted son Rock, both of whom have very different reasons for wanting to find her.

In Tokyo, a weak, unassertive boy named Sena Kobayakawa enters the high school of his choice, Deimon Private Senior High School. Sena's only remarkable physical abilities are his running speed and agility, which are noted by the school's American football team captain Yoichi Hiruma. Hiruma forces Sena to join the Deimon Devil Bats football team as its running back. To protect his identity from other teams who want to recruit him, Sena is forced to publicly assume the role of the team secretary and enter the field under the pseudonym of "Eyeshield 21" wearing a helmet with an eyeshield to hide his features.