Patsy McCartle is a widow with two sons trying to gather all the money she has to pay for her car, bills, and her son's medication, all of which she can barely afford. She turns to dealing drugs and becomes addicted to crystal meth.
Based upon the book and real-life story of FBI profiler Candice DeLong, "Killer Instinct" chronicles DeLong's pursuit of a serial killer who, after attacking her close friend, chooses her as his next victim.