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Anime Talk Show (also known as Adult Swim Brain Trust) is an animated television special that aired on Cartoon Network's late night programming block, Adult Swim, on November 4, 2004. Anime Talk Show revolved around the unofficial pilot for Squidbillies, however many people consider it the very last episode of Space Ghost, as it follows exactly the same format of the show, with Space Ghost interviewing guests. The short was dubbed "Anime Talk Show" due to it following the premiere of Perfect Hair Forever, which aired in place of what was supposed to have been the premiere of Squidbillies.

Squidbillies is an animated television series about the Cuylers, an impoverished family of anthropomorphic hillbilly mud squids living in the Appalachian region of Georgia's mountains. The show is produced by Williams Street Studios for the Adult Swim programming block of Cartoon Network and premiered on October 16, 2005. It is written by Dave Willis, co-creator of Aqua Teen Hunger Force, and Jim Fortier, previously of The Brak Show, both of whom worked on the Adult Swim series Space Ghost Coast to Coast. The animation is done by Awesome Incorporated, with background design by Ben Prisk.