Harvard symbologist Robert Langdon is recruited by the Vatican to investigate the apparent return of the Illuminati – a secret, underground organization – after four cardinals are kidnapped on the night of the papal conclave.
Susan Keane is a glamorous San Francisco magazine writer beginning to adjust to being single, who learns to be independent-minded, after being taken care of all her life.
Ryan Atwood, a teen from the wrong side of the tracks, moves in with a wealthy family willing to give him a chance. But Ryan's arrival disturbs the status quo of the affluent, privileged community of Newport Beach, California.
Sydney Bristow, an agent who has been tricked to believe she is working for the U.S. government, is actually working for a criminal organization named the Alliance of Twelve. Upon learning this, Sydney becomes a double agent for the real CIA.