Actor-filmmaker Peter Vack decides to re-identify as female to maintain relevance in the art and entertainment world. This horrifies Peter's sister Betsey and makes her spiral deep into a mania of sibling rivalry as she desperately searches for her own artistic voice.
Adah and Aaron are recovering addicts who are struggling to stay sober. After meeting in their psychoanalyst’s waiting room, they fall in love, relapse on poppers, and become the biggest assholes in New York City.