Jo's world is thrown into utter disarray when her wife Amanda passes away and she starts chasing a dream that she and Amanda had once shared - starting a family together. Jo asks her late wife's brother, Jamie, to be her sperm donor and craziness ensues.
Ray Barone is a successful sportswriter living on Long Island with his wife Debra, daughter Ally, and twin sons, Geoffrey and Michael. Ray's meddling parents, Frank and Marie, and brother, Robert, live directly across the street.