Picking up directly where the previous film left off, the story follows Riley, one of the last people to come in contact with Samantha, as he scrambles to track down those responsible for the outbreak before the highly contagious disease not only consumes his body, but the world as we know it.
Marissa, an excited bride-to-be, turns into a raging "bridezilla", when she learns her maid of honor has lost her bouquet. Furious about her missing flowers, she throws a hysterical fit, until a tragic accident unravels her momentous day.