In 1587, more than 100 English colonists settle on Roanoke Island and soon vanish, baffling historians for centuries; now, experts use the latest forensic archaeology to investigate the true story behind America's oldest and most controversial mystery.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.