On the afternoon of July 1, 1981, Los Angeles police responded to a distress call on Wonderland Avenue and discovered a grisly quadruple homicide. The police investigation that followed uncovered two versions of the events leading up to the brutal murders - both involving legendary porn actor John Holmes.
Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.