As humanity picks up the pieces, following the conclusion of "Transformers: Dark of the Moon," Autobots and Decepticons have all but vanished from the face of the planet. However, a group of powerful, ingenious businessman and scientists attempt to learn from past Transformer incursions and push the boundaries of technology beyond what they can control - all while an ancient, powerful Transformer menace sets Earth in his cross-hairs.
As an epidemic of a lethal airborne virus - that kills within days - rapidly grows, the worldwide medical community races to find a cure and control the panic that spreads faster than the virus itself.
The Autobots continue to work for NEST, now no longer in secret. But after discovering a strange artifact during a mission in Chernobyl, it becomes apparent to Optimus Prime that the United States government has been less than forthright with them.
Chicagoan Frank Gallagher is the proud single dad of six smart, industrious, independent kids, who without him would be... perhaps better off. When Frank's not at the bar spending what little money they have, he's passed out on the floor. But the kids have found ways to grow up in spite of him. They may not be like any family you know, but they make no apologies for being exactly who they are.