Mary is slowly succumbing to dementia in a Sanatorium. She knows that her condition is irreversible and time is not on her side.
After Portland homicide detective Nick Burkhardt discovers he's descended from an elite line of criminal profilers known as "Grimms," he increasingly finds his responsibilities as a detective at odds with his new responsibilities as a Grimm.
Three years after the zombie virus has gutted the country, a team of everyday heroes must transport the only known survivor of the plague from New York to California, where the last functioning viral lab waits for his blood.