All the vampires have to take a special potion made by Ghyslain Chabot to be human. Chabot's wife isn't a vampire yet but wishes to become one. Ghyslain doesn't share her desire because of all the rules and responsibilities inherent in being a vampire. As a result, Ghyslain's wife throws him out of the house without the potion.
The show follows a special police unit dedicated to fighting organized crime and major criminal networks, including street gangs, biker gangs, Italian/Irish/Lebanese mafias, and Mexican cartels.