In the year 2524, four centuries after humans started colonizing the outer planets, retired General James Ford gets called back into service when a hostile alien fleet attacks soldiers on a remote planet. The threat against mankind soon escalates into an interstellar war as Ford and a team of elite soldiers try to stop the imminent attack before it's too late.
A tough, brilliant senior resident guides an idealistic young doctor through his first day, pulling back the curtain on what really happens, both good and bad, in modern-day medicine.
Lifelong friends Maddie, Helen and Dana Sue lift each other as they juggle relationships, family and careers in the small, Southern town of Serenity.