Flo and his trusted Collie pal Lassie spend the summer at Aunt Cosma's, alongside her foster children Kleo and Henry, and her dog Pippa. When local canines start disappearing, including Pippa, Lassie rallies the kids to solve the mystery.
When surgeon Eric Leonhard's pregnant wife goes missing, all signs point back to him. Believing she is still alive, Eric follows a chilling lead on board a cruise and lands a job as the ship's doctor to uncover the truth behind her disappearance.