Peter Parker must decide if picking back up his responsibilities as Spider-Man and helping Scarlet Spider stop The Goblin is more important than his personal happiness.
In denial of the truth behind his Uncle's death, Peter Parker must discover what kind of hero he wants to be. All the while, Doctor Octopus and the Sinister Six are tearing apart New York City.
As tensions between mankind and the mutants begin to rise, Spider-Man discovers that the sinister Green Goblin has a hand in the escalating conflict.
In an alternate universe... The fledgling hero known as the Ghost-Spider struggles to be the hero she's meant to be after a personal loss. But when the Kingpin threatens to take away everything, she must face the music and do what's right.