Mayamma revolves around the love between a Naboothiri boy and a Pulluvathi girl and the subsequent conflicts that the Pulluvathi has to face and her struggles for womanhood and pride.
Three childhood friends Mathukutty, Binoy and Zachariah re-unite in Goa to fight a Casino don who was responsible for the deaths of their fathers.
Hari, a village boy, travels to Varanasi to pursue higher studies. However, he falls into trouble after he unintentionally cheats on his girlfriend, Devu, with his classmate, Amritha.
Dr. Ruben joins a mental hospital and immediately attracts attention due to his humane ways of dealing with the patients. This irks the hospital management, especially the Managing Director, Dr. Rakhi. However, soon another person surfaces and claims to be the real Dr. Ruben
A brilliant lawyer turns alcoholic due to failure in love and ends up losing his job. His life changes for the better when a young woman approaches him to save her life and wealth.