Roy Rogers is a cowboy who joins the Border Patrol, only to have his buddy Tommy get killed at a local saloon. Determined to get revenge at any cost, Roy and Rusty cross the border in search of Arizona Jack, the man responsible for Tommy's death.
Imprisoned for a murder he did not commit, John Brant escapes and ends up out west where, after giving the local lawmen the slip, he joins up with an outlaw gang. Brant finds out that 'Jones', one of the outlaws he has become friends with, committed the murder that Brant was sent up for, but has no knowledge that anyone was ever put in jail for his crime. Willing to forgive and forget, Brant doesn't realize that 'Jones' has not only fallen for the same pretty shopgirl Brant has, but begins to suspect that Brant is not truly an outlaw.
Bob arrives looking for the killer of his uncle. When the Sheriff chases him and his partner Rusty, Reno thinks they are the men he is looking for and takes them into his gang. There Bob finds his uncle's gun and knows he has found the right gang. However he realizes the gang has an unknown leader and he sets out to find him.
When Tex is brought in to fight in a range war between the cowmen and the nesters, he meets his old outlaw boss Lassiter. He learns Lassiter is behind the feud when Lassiter asks him to join up with his gang. Tex refuses and instead sets out to stop the feud but no one will believe him that Lassiter is responsible.
Tex and his sidekicks arrive to help out his friend Jeffers, a railroad owner, only to find that he has been killed. They quickly run into trouble with an outlaw gang in their attempt to find the mysterious ghost train that supposedly runs on Jeffer's line.
Montana Rivers finally escapes her father who had forced her to wear men's clothing and help in robbing and cheating. She is taken in by friendly Indians and stays at their camp. Later, Akkomi, chief of the tribe, asks his friend Dan Overton to take the girl as it is not good for her to remain in the camp. Dan provides for "Tana" and falls in love with her but, because of her past, she keeps him at a distance. Jim Harris comes by and recognizes Tana as the boy robber, but when he attempts to blacken her past, Dan gives him a beating which paralyzes him. Jim then stays on with Dan, who regrets his hastiness. Eventually Tana's father appears and demands that Tana go away with him. She refuses but also does not tell Dan of this trouble.
The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
Female outlaw helps lawmen trap railroad bandits.
Narrowly escaping death, outlaw Johnny Madrid goes on the run with the hangman's sensuous daughter Esmeralda by his side.
Dusty Gardner, and other Texas ranchers, are driving a herd of cattle to Abilene, Kansas along the Chisholm Trail. Desperate need of water takes them to the Turner ranch, where Belle Turner demands exorbitant prices for the water. Dusty learns that Belle is also trying to oust Mary Lee and Montana Smith from the trading post Mary operates. The sheriff sides with Belle following a fight between the two women. Belle knows there is artesian springs under the land the trading post occupies and intends to get the property by any means.
U.S Marshal Mike Donovan has dark memories of the death of his first love. He keeps peace between the Americans and the natives who had temporarily adopted and taken care of him. The evil actions of a white sorcerer lead him to confront the villain in the Sacred Mountains, and, through shamanic rituals conquer his fears and uncover a suppressed memory he would much rather deny.
The James and Younger outlaw gangs ride into town, and it is up to the local marshal, who has lost both his nerve and his gun skills, to stop them.
Bank robber Graham Dorsey spends a few hours with beautiful widow Amanda Starbuck, in which time his gang takes part in a disastrous holdup. Learning of his comrades' demise, Dorsey goes on the lam. Believing her short-term lover was killed by the law, Amanda decides to make the most of having had a liaison with the supposedly deceased desperado by writing a book about him. Much to his confusion, the still-living Dorsey watches as his name becomes legendary.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Three of the original five "young guns" — Billy the Kid, Jose Chavez y Chavez, and Doc Scurlock — return in Young Guns, Part 2, which is the story of Billy the Kid and his race to safety in Old Mexico while being trailed by a group of government agents led by Pat Garrett.
Expert conman Joe Thanks teams up with half-breed Bill and naive Lucy to steal $300,000 from the Indian-hating Major Cabot. Their elaborate plan is full of disguises, double-crosses, and chases, but Joe always seems to know what he's doing.
Singing cowboy Whip Wilson, the foreman on a cattle drive, quits his job to pursue five bank robbers who murdered his brother.
Questions arise when Senator Stoddard (James Stewart) attends the funeral of a local man named Tom Doniphon (John Wayne) in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance (Lee Marvin). As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
A sexy nightclub owner, Barb Wire moonlights as a mercenary in Steel Harbor, one of the last free zones in the now fascist United States. When scientist Cora Devonshire wanders into Barb's establishment, she gets roped into a top-secret government plot involving biological weapons. Soon Barb is reunited with her old flame Axel Hood, who is now Cora's husband and a guerrilla fighter, resulting in plenty of tense action.
The epic tale of the development of the American West from the 1830s through the Civil War to the end of the century, as seen through the eyes of one pioneer family.