The lives of several individuals intertwine as they go about their lives in their own unique ways, engaging in acts which society as a whole might find disturbing in a desperate search for human connection.
A street-wise kid, Mark Sway, sees the suicide of Jerome Clifford, a prominent Louisiana lawyer, whose current client is Barry 'The Blade' Muldano, a Mafia hit-man. Before Jerome shoots himself, he tells Mark where the body of a Senator is buried. Clifford shoots himself and Mark is found at the scene, and both the FBI and the Mafia quickly realize that Mark probably knows more than he says.
A woman watches time pass beside the suitcases of her ex-lover (who is supposed to come pick them up but never arrives) and a restless dog who doesn't understand that his master has abandoned him.
A young woman of good family is driven into one of thieves and prostitutes and ends in suicide.
An alcoholic ex-football player drinks his days away, having failed to come to terms with his sexuality and his real feelings for his football buddy who died after an ambiguous accident. His wife is crucified by her desperation to make him desire her: but he resists the affections of his wife. His reunion with his father—who is dying of cancer—jogs a host of memories and revelations for both father and son.
The family of a wealthy businessman gather to celebrate his 60th birthday. During the course of the party, his eldest son presents a speech that reveals a shocking secret.
A drama focused on the friendship between a high-functioning autistic woman and a man who is traumatized after a fatal car accident.
Sharon appears to be a normal 17-year-old girl with good grades, many friends, and a wonderful personality - hardly someone you think would be considering suicide. But her home life is constrained by the pressures and expectations of her parents. She slowly spirals downward, her mother at one point telling her that she has no business being unhappy. So, she gulps down a bottle of sleeping pills. She is saved, but for how long?
Rufus is a shy and lonely boy determined to make a new start. Sure he has some quirks. So what if he likes the taste of blood? It's not like he's addicted. When a cunning vampire hunter slips into town searching for the fountain of youth, Rufus fears his darkest secret is about to be revealed.
The young Harold lives in his own world of suicide-attempts and funeral visits to avoid the misery of his current family and home environment. Harold meets an 80-year-old woman named Maude who also lives in her own world yet one in which she is having the time of her life. When the two opposites meet they realize that their differences don’t matter and they become best friends and love each other.
An average, everyday metalworker and volunteer firefighter content in his marriage to his childhood sweetheart finds his emotions unexpectedly stirred when he falls for a pretty waitress from a nearby town.
When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.
Tullio Hermil is a chauvinist aristocrat who flaunts his mistress to his wife, but when he believes she has been unfaithful he becomes enamored of her again.
Derek loves the blues, even outside his on stage perfomances. When the singer wakes up in a mental institution after a suicide attempt, he meets Adam, his devoted fan and a true pain in the ass. A story about two guitars, three chords and the beginning of a friendship.
A young Frenchman arrives in Northern California looking to forget a lost love and ends up encountering various forms of feminine power.
Paul, a young idealist trying to figure out what he wants to do with his life, takes a job interviewing people for a marketing research firm. He moves in with aspiring pop singer Madeleine. Paul, however, is disillusioned by the growing commercialism in society, while Madeleine just wants to be successful. The story is told in a series of 15 unrelated vignettes.
Pablo, a successful film director, disappointed in his relationship with his young lover, Juan, concentrates in a new project, a monologue starring his transgender sister, Tina. Antonio, an uptight young man, falls possessively in love with the director and in his passion would stop at nothing to obtain the object of his desire.
A mentally ill young woman finds her love in an eccentric man who models himself after Buster Keaton.
The lives of a recovering addict and her single mother change forever when they move in next door to a widowed father and his adult daughter with autism.
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