When Jerry rustles cheese from the Dry Gulch General Store, Sheriff Mutt Dillin hires Tom, the fastest trap in the West.
On a snowy night in the city, Jerry is comfortably asleep in his hole inside a penthouse, while Tom tries to keep from freezing to death in the alley below.
Jerry runs into the Metropolitan Opera, trying to evade Tom.
Tom, famous baritone Signor Thomasino Catti-Cazzaza, enthralls a concert audience with his rendition of "Largo al factotum", from Rossini's "Il Barbiere di Siviglia", while Jerry strives for sleep under the stage.
Waif mouse Jerry, encrusted with snow, peers through a warmly lit window at Tom asleep by the fire in a room full of cheese.
Tom enjoys the role of top cat until an adorable red-and-white-haired kitten is brought into the house of a young blonde woman.
Little Cheeser is a young mouse who thinks he's more grown up than he is. Mama tells him to go to bed, calling him "Mama's little man"; he doesn't want to. His devil side emerges and guides him to the cheese in the pantry, where his angel side appears to stop him. The devil leads him on to the smoking supplies, where he lights a pipe, then to a racy magazine, and then to the booze. The soused Cheeser goes looking for the cat, but when he finds it, the reality sobers him up quickly. The devil, meanwhile, has been trapped in a copy of Dante's Inferno by the angel. The angel helps Cheeser escape, and he's all too happy to go to bed and be Mama's little man.
Scheming mice Hubie and Bertie convince a cat that he is, in fact, a lion.
Mice Hubie and Bertie wander into an automated house of tomorrow.
A starving cat wandering in the wilderness sees a sign that says "Ma's Place / Home Cooking / 3 Miles". The cat speeds into town, without noticing the sign that says "Ghost Town / Population 100 Ghosts". One of these ghosts is a mouse eager to get revenge on cats for having tormented him in life.
Sniffles the mouse has to get an owl's egg for a scavenger hunt, but once he's gotten it, the egg hatches and draws the attention of the mouse-eating father owl.
Sniffles the mouse's non-stop talking foils both the burglar and a tipsy Officer Bear, who's trying to sneak past his rolling pin-toting, sleepwalking wife.
A drunken stork delivers a baby mouse to the home of Mr. and Mrs. Sylvester Cat. Sylvester is about to eat the little rodent when it calls him Daddy. Touched, Sylvester adopts the mouse as his son - which, distressingly, attracts every hungry cat in the neighborhood to his door!
Popeye's snoring is keeping his resident mouse awake. The mouse fights back.
A mouse, sleeping in the Zowie Cafe, has his sleep disturbed by the jukebox.
Sniffles the mouse and his friend the Bookworm decide to take up egg collecting, setting their eyes upon a big barn owl egg. But the big barn owl isn't so hot on the idea.
Sniffles the mouse is in the country for a restful vacation of fresh air, enjoyment of nature, and peace and quiet.
Sniffles the mouse's friends talk him into putting a bell around the neck of the troublesome house cat.
Sniffles the mouse and his friend the Bookworm try to evade a cat in a the toy department of Lacy's department store.
Mickey, Minnie, Horace Horsecollar, and Clarabelle Cow go on a musical wagon ride until Peg-Leg Pete tries to run them off the road.