Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
Thomas hitchhikes from Hamburg to Munich where he meets his ex-girlfriend, Peggy. Thomas doesn't have a bed for the night and goes home with Peggy, not knowing that she and her four roommates have all made a strange pact.
While driving through the New Mexico Desert during a rainy night, college students Jim Halsey and his girlfriend Grace Andrews give a ride to a hitchhiker. While in their car, the stranger proves to be a psychopath threatening the young couple with a knife, but Jim successfully throws him out of the car. This sets off a chain of events that will change all of their lives forever.
Zia, distraught over breaking up with his girlfriend, decides to end it all. Unfortunately, he discovers that there is no real ending, only a run-down afterlife that is strikingly similar to his old one, just a bit worse. Discovering that his ex-girlfriend has also "offed" herself, he sets out on a road trip to find her.
One evening, Hammer gives a ride to Christina, an attractive hitchhiker on a lonely country road, who has escaped from the nearby lunatic asylum. Thugs waylay them and force his car to crash. When Hammer returns to semi-consciousness, he hears Christina being tortured until she dies. Hammer, both for vengeance and in hopes that "something big" is behind it all, decides to pursue the case.
Sally (Mikayla Deane) is having trouble with her relationship and decides that she might start a fling with Howard (Juan Suarez), the new guy at work. Only when she accepts a ride home, she soon realizes he may be more murderous than he appears.
Set in 1964, a three-day journey along Route 66 begins when Bobby Falls, a 19-year-old serial killer, hitches a ride with Jim Goodwin, a celebrity animal handler travelling with his precious cargo: his TV chimpanzee, Spanky.
Gifted but hot-headed sculptor Eric has a stormy, erotic, and star-crossed romance with a beautiful young woman named Olga.
Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.
On their way to an afternoon on the lake, husband and wife Andrzej and Krystyna nearly run over a young hitchhiker. Inviting the young man onto the boat with them, Andrzej begins to subtly torment him; the hitchhiker responds by making overtures toward Krystyna. When the hitchhiker is accidentally knocked overboard, the husband's panic results in unexpected consequences.
Wildcatter Johnny Maverick and his pal go to a town in oil country offering $25,000 to the person who brings in the first well. They find oil on the outskirts but have to sell a share to a promoter who hires Johnny's old enemy.
After FBI agent Frank Lacrosse believes his son was kidnapped by a notorious serial killer, he travels to Amarillo, Texas, where he believes the murderer is in hiding. Although officially taken off the case because of its personal significance to him, Frank continues to pursue the killer, causing concern for local sheriff Buck Olmstead. When another victim pops up at a nearby car garage, Frank knows that he is as close as he'll ever be to tracking down the elusive killer.
Two young hitch-hikers on a spree of revenge.
On a stormy night, young Jim, who transports a luxury car from Chicago to California to deliver it to its owner, feeling tired and sleepy, picks up a mysterious hitchhiker, who has appeared out of nowhere, thinking that a good conversation will help him not to fall asleep. He will have enough time to deeply regret such an unmeditated decision.
A young woman stumbles into a nightmare land of hijacking and humiliation while driving cross-country from California to New York.
Steve Morgan kills a man in a holdup and hitches a ride to Los Angeles with Fergie. At a gas station, they pick up two women. Encountering a roadblock, Morgan takes over and persuades the party to spend the night at an unoccupied beach house. The police close in as one by one, the others learn that Morgan is a killer.
At the pointy end of a situationship and a sexuality crisis, Georgia and Jake are stuck on the side of the road with an overstepping hitchhiker on a trip that will either make or break them – or maybe both.
When a young boy decides to hitchhike to get to a nearby village, he has no idea of the driver's true intentions.
Howard is mild-mannered and slightly simple-minded, with a habit of picking up teenage hitchhikers while driving his delivery routes. Sometimes the girls admit to being runaways, and if they claim to hate their mothers it drives Howard into a violent frenzy; his sister ran away from home years ago and was never heard from again, causing his desperate, addled mother to tighten her hold on him. Howard never remembers raping his victims or strangling them with wire coat hangers, though his boss does notice missed deliveries and late arrivals.
A computer expert embezzles half a million dollars and races off to Reno to start anew. Unfortunately, en route, he picks up a pair of hitchers and ends up entangled with a crazed couple who commandeer his car and leave him alone in the desert to die. As soon as he can, he hits the road to get revenge and to find his money before they do.