Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
A woman on the run from her abusive husband encounters a mysterious hitch-hiker.
Taking a break from their dreary lives, close friends Thelma and Louise embark on a short weekend trip that ends in unforeseen incriminating circumstances. As fugitives, both women rediscover the strength of their bond and their newfound resilience.
After FBI agent Frank Lacrosse believes his son was kidnapped by a notorious serial killer, he travels to Amarillo, Texas, where he believes the murderer is in hiding. Although officially taken off the case because of its personal significance to him, Frank continues to pursue the killer, causing concern for local sheriff Buck Olmstead. When another victim pops up at a nearby car garage, Frank knows that he is as close as he'll ever be to tracking down the elusive killer.
Monette, a recently separated travelling book salesman tells his grim story to both a priest and a hitchhiker, looking for absolution.
Thomas hitchhikes from Hamburg to Munich where he meets his ex-girlfriend, Peggy. Thomas doesn't have a bed for the night and goes home with Peggy, not knowing that she and her four roommates have all made a strange pact.
While driving through the New Mexico Desert during a rainy night, college students Jim Halsey and his girlfriend Grace Andrews give a ride to a hitchhiker. While in their car, the stranger proves to be a psychopath threatening the young couple with a knife, but Jim successfully throws him out of the car. This sets off a chain of events that will change all of their lives forever.
Kowalski works for a car delivery service, and takes delivery of a 1970 Dodge Challenger to drive from Colorado to San Francisco. Shortly after pickup, he takes a bet to get the car there in less than 15 hours.
A young man is in a race against time as he searches for a cure after becoming infected with a virus that will eventually turn him into a blood-sucking vampire.
One evening, Hammer gives a ride to Christina, an attractive hitchhiker on a lonely country road, who has escaped from the nearby lunatic asylum. Thugs waylay them and force his car to crash. When Hammer returns to semi-consciousness, he hears Christina being tortured until she dies. Hammer, both for vengeance and in hopes that "something big" is behind it all, decides to pursue the case.
Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.
In this Franco-Italian gangster parody, a shopkeeper on his way to an Italian holiday suffers a crash that totals his car. The culprit can only compensate his ruined trip by driving an American friend's car from Naples to Bordeaux, but as it happens to be filled with such contraband as stolen money, jewelry and drugs, the involuntary and unwitting companions in crime soon attract all but recreational attention from the "milieu".
A young woman stumbles into a nightmare land of hijacking and humiliation while driving cross-country from California to New York.
Wildcatter Johnny Maverick and his pal go to a town in oil country offering $25,000 to the person who brings in the first well. They find oil on the outskirts but have to sell a share to a promoter who hires Johnny's old enemy.
On their way to an afternoon on the lake, husband and wife Andrzej and Krystyna nearly run over a young hitchhiker. Inviting the young man onto the boat with them, Andrzej begins to subtly torment him; the hitchhiker responds by making overtures toward Krystyna. When the hitchhiker is accidentally knocked overboard, the husband's panic results in unexpected consequences.
A sadistic serial killer terrorizes a couple driving on a rural highway in Texas while killing numerous people and framing them for his killings.
Charles and Meg, a young couple whose relationship is currently experiencing some distress, go on vacation in Paestum hoping to mend their problems. But along the way they pick up an aggressive and unscrupulous hitchhiker.
Chasing a memory, Alex is determined to drive cross-country to Melbourne. Planning on having just the highway for company, he reluctantly picks up a hitchhiker running from something with as much determination as Alex is running to something.
After a group of Texas teenagers leave prom night early and get into a car crash in the woods, they employ the aid of a nearby insurance agent, who calls in her tow truck-driving boyfriend, Vilmer Slaughter. Unfortunately for them, Vilmer is a sadistic killer with a mechanical leg who introduces them to his brother, Leatherface, and the rest of their twisted family.
Joe and Paul Fabrini are Wildcat, or independent, truck drivers who have their own small one-truck business. The Fabrini boys constantly battle distributors, rivals and loan collectors, while trying to make a success of their transport company.