Whilst on a short weekend getaway, Louise shoots a man who had tried to rape Thelma. Due to the incriminating circumstances, they make a run for it and thus a cross country chase ensues for the two fugitives. Along the way, both women rediscover the strength of their friendship and surprising aspects of their personalities and self-strengths in the trying times.
Judy Wilson (Gale Storm), feeling neglected because both of her parents are working in defense plants, meets and falls in love with Danny Chester (Jackie Cooper), who enlists in the Navy and is sent to San Diego for training. She accepts an invitation to go on a ride to San Diego with her friends Herb (Neyle Morrow), Opal (Evelyn Eaton)and Jerry (Jimmy Zahner) but doesn't know the car has been stolen.
Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
On a stormy night, young Jim, who transports a luxury car from Chicago to California to deliver it to its owner, feeling tired and sleepy, picks up a mysterious hitchhiker, who has appeared out of nowhere, thinking that a good conversation will help him not to fall asleep. He will have enough time to deeply regret such an unmeditated decision.
Monette, a recently separated travelling book salesman tells his grim story to both a priest and a hitchhiker, looking for absolution.
A young man is in a race against time as he searches for a cure after becoming infected with a virus that will eventually turn him into a blood-sucking vampire.
Kowalski works for a car delivery service, and takes delivery of a 1970 Dodge Challenger to drive from Colorado to San Francisco. Shortly after pickup, he takes a bet to get the car there in less than 15 hours.
Zia, distraught over breaking up with his girlfriend, decides to end it all. Unfortunately, he discovers that there is no real ending, only a run-down afterlife that is strikingly similar to his old one, just a bit worse. Discovering that his ex-girlfriend has also "offed" herself, he sets out on a road trip to find her.
The life of Al Roberts, a pianist in a New York nightclub, turns into a nightmare when he decides to hitchhike to Los Angeles to visit his girlfriend.
Joe and Paul Fabrini are Wildcat, or independent, truck drivers who have their own small one-truck business. The Fabrini boys constantly battle distributors, rivals and loan collectors, while trying to make a success of their transport company.
A sadistic serial killer terrorizes a couple driving on a rural highway in Texas while killing numerous people and framing them for his killings.
A young woman stumbles into a nightmare land of hijacking and humiliation while driving cross-country from California to New York.
When a young boy decides to hitchhike to get to a nearby village, he has no idea of the driver's true intentions.
Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.
A truck driver plays a cat-and-mouse game with a mysterious serial killer in a van who lures young female hitchhiker victims on a desolate Australian highway.
American Neil Bowman is traveling through France when he meets British photographer Lila. They are hired by French land owner Duc de Croyter to escort a Hungarian scientist to New York. But they soon realize that the job is not a cushy number, and have to deal with a gang of kidnappers who will stop at nothing to get their hands on the scientist
Roy and Gilbert's fishing trip takes a terrifying turn when the hitchhiker they pick up turns out to be a sociopath on the run from the law. He's killed before, and he lets the two know that as soon as they're no longer useful, he'll kill again. The two friends plot an escape, but the hitchhiker's peculiar physical affliction, an eye that never closes even when he sleeps, makes it impossible for them to tell when they can make a break for it.
Wildcatter Johnny Maverick and his pal go to a town in oil country offering $25,000 to the person who brings in the first well. They find oil on the outskirts but have to sell a share to a promoter who hires Johnny's old enemy.
Three young New York men decide to travel South for a few days away from the Big Apple. They pick up a beautiful, mysterious young sight less woman with a strange and unsettling past. All three are captivated and fascinated by her, but can she be trusted?
Peter Highman must scramble across the US in five days to be present for the birth of his first child. He gets off to a bad start when his wallet and luggage are stolen, and put on the 'no-fly' list. Peter embarks on a terrifying journey when he accepts a ride from an actor.