The corpse of a shabbily dressed young woman has been discovered in the mud flats of the Thames at low tide. Police assume she's a prostitute, but Dr. Watson suspects something more and goes to his old friend Holmes, now retired and at very loose ends.
Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider.
Having once again avoided criminal conviction, Professor Moriarity develops a murderous plan to “finish off” his last major nemesis, Sherlock Holmes, by making him fail to prevent the perfect crime. Does it involve a family curse, the crown jewels of England, or something else…
When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.
Sherlock Holmes and Dr. Watson meet as boys in an English Boarding school. Holmes is known for his deductive ability even as a youth, amazing his classmates with his abilities. When they discover a plot to murder a series of British business men by an Egyptian cult, they move to stop it.
The Good Comrades are a collection of varied gentlemen who crave one thing - solitude. They reside at Drearcliff House, ancestral home of their eldest member. All seems serene and convivial until one by one the members begin to perish in the most grisly of manners. Foul play is suspected by the Good Comrades' insurance agent, who turns to Sherlock Holmes and Dr. John Watson for guidance.
The famous Borgia Pearl, a valuable gem with a history of bringing murder and misfortune to its owner since the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But before long the jewel is stolen, due to an error on Holmes' part, and shortly thereafter, a series of horrible murders begin, the murderer leaving his victims with their spines snapped and surrounded by a mass of smashed china.
When a woman is found dead with her throat torn out, the local villagers blame a supernatural monster. But Sherlock Holmes, who gets drawn into the case from nearby Quebec, suspects a human murderer.
Sherlock Holmes is drawn into the case of Jack the Ripper, who is killing prostitutes in London's East End. Assisted by Dr. Watson, and using information provided by a renowned psychic, Robert Lees, Holmes finds that the murders may have their roots in a Royal indiscretion and that a cover-up is being managed by politicians at the highest level, all of whom happen to be Masons.
Sherlock Holmes investigates when young women around London turn up murdered, each with a finger severed. Scotland Yard suspects a madman, but Holmes believes the killings to be part of a diabolical plot.
Sherlock Holmes and Watson are on the trail of a criminal and scientific mastermind who seems to control monsters and creations which defy belief.
In World War II, a British secret agent carrying a vitally important document is kidnapped en route to Washington. The British government calls on Sherlock Holmes to recover it.
Holmes takes a vacation and visits his old friend Sir Henry Baskerville. His vacation ends when he suddenly finds himself in the middle of a double-murder mystery. Now he's got to find Professor Moriarty and the horse Silver Blaze before the great cup final horse race.
In London, a secret society led by lawyer Thaddeus Merrydew collects the assets of any of its deceased members and divides them among the remaining members. Society members start dropping like flies. Sherlock Holmes is approached by member James Murphy's widow, who is miffed at being left penniless by her husband. When Captain Pyke is shot, Holmes keys in on his mysterious Chinese widow as well as the shady Merrydew. Other members keep dying: Malcom Dearing first, then Mr. Baker. There is also an attempt on the life of young Eileen Forrester, who became a reluctant society member upon the death of her father. Holmes' uncanny observations and insights are put to the test.
Sherlock Holmes and Dr. Watson embark on a search for Cleopatra's ancient necklace, which has been stolen.
When Watson reads from the newspaper there have been two similar murders near Whitechapel in a few days, Sherlock Holmes' sharp deductive is immediately stimulated to start its merciless method of elimination after observation of every apparently meaningless detail. He guesses right the victims must be street whores, and doesn't need long to work his way trough a pawn shop, an aristocratic family's stately home, a hospital and of course the potential suspects and (even unknowing) witnesses who are the cast of the gradually unraveled story of the murderer and his motive.
Sherlock Holmes is a master at solving the most impenetrable mysteries, but he has his work cut out for him on his latest case. As the famed detective investigates an alleged theft, he’s brought face to face with his most devious adversary yet — Professor Moriarty.
In a mansion full of secret rooms and passageways, people are dying shortly after seeing the ghost of a woman in gray, as an old legend dictates. Called in to solve the mystery, Sherlock Holmes has doubts about the supernatural aspect of the crimes and focuses on a more earthly culprit.
Holmes, retired to Sussex, is drawn into a last case when his arch enemy Moriarty arranges with an American gang to kill one John Douglas, a country gentleman with a mysterious past. Holmes' methods baffle Watson and Lestrade, but his results astonish them. In a long flashback, the victim's wife tells the story of the sinister Vermissa Valley.