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Emma's daughter Kendall becomes engaged, but Emma is concerned as Kendall and her fiancé have Down Syndrome and Emma worries she's not ready to take this step.

A gentle tale of love told in halting words. A film about healing after profound loss. John and Michael pays homage to two men with Down's syndrome who shared an intimate and profoundly loving relationship that deeply affected the filmmaker. Animated with clay backlit on glass, the film shimmers like stained glass in motion. Narrator Brian Davis, also intellectually challenged, brings the men alive with great sensitivity. The audience shares in the various emotions that infuse their everyday living. John and Michael, by its artistry, rises above society's traditional ideas around disability, sexuality and death. When the heart is touched, differences melt. Love is what defines humanity.

Vito is a sweet little boy with Down syndrome, and this short documentary puts his energetic, jolly personality on full display as he interacts with his loving family. By showing Vito’s dignity and inherent value, Vito-Man tackles the difficult conversation that is the eradication of people with Down syndrome, proving that an extra chromosome should not be a death sentence.

Amanda is reluctantly tasked with taking care of her new classmate, Lars, who has Down syndrome. To her surprise, Amanda and Lars develop a unique friendship. But in her struggle to fit in, Amanda ends up betraying Lars. Can Amanda find the courage to stand out and be true to herself?

Jeannot has Down’s Syndrome. Living in a claustrophobic suburban setting, he is treated like a child by his parents and denied any responsibilities of his own. Things change when a young woman named Pauline is hired to take care of Jeannot, and his world opens up beyond the restrictive one imposed upon him.

In the beginning of the 19th century, Johannes Elias Alder is born in a small village in the Austrian mountains. While growing up he is considered strange by the other villagers and discovers his love of music, especially rebuilding and playing the organ at the village church. After experiencing an "acoustic wonder", his eye color changes and he can hear even the most subtle sounds.

A week away from leaving for his first year of college, Michael starts to become frustrated with his parent's overprotective tendencies toward his teen brother Nathan, who has Down syndrome.

Astrid is a comedian who makes people laugh for a living; her husband Markus is her manager and the two of them work well together. They have a nine-year-old daughter and are expecting their second child. When they learn that their child will not be born healthy, they are at first optimistic that they will be able to meet this challenge – although they have no idea what awaits them. But the closer it gets to the due date, the more Astrid begins to worry about the future of her unborn child as well as that of her family and her career. After many discussions and arguments Astrid realises that the decision that will affect all their lives must be made by her alone. What complicates matters further is the fact that, as a successful entertainer, she is in the eye of the public and the media.

In 1994, two brothers are enjoying the summer that will change everything: the youngest, Lucas, is starting school and will have to accept that his older brother, Bruno, who has Down syndrome, will not take part on this new adventure.

At The Kingdom, Denmark's most technologically advanced hospital, a number of strange and otherworldly events begin occurring, much to the dismay of its doctors and patients. A ghostly ambulance appears and disappears, the voice of a little girl calls to a patient in an elevator shaft, and a doctor's fetus begins growing at an alarming rate.

The Bachmann family's life is falling apart at the seams. Little Florian needs his dad - Peter Bachmann. Peter, his wife Maria and daughter Sophie have been unaware of his existence until now. A test begins. Can Maria forgive her husband for his infidelity? Should they really take the strange child into their family? When they finally decide in favor of Florian, they learn that he is no ordinary child. He is a boy with Down's syndrome. They are shocked. Once again their love is put to the test. Will she be big enough to accept Florian?

Luke, an independent young man with Down's syndrome stumbles upon a wild and life changing friendship.

During a blizzard in 1964, Dr. David Henry delivers his son Paul with the help of nurse Caroline. But when Henry realizes his wife is also carrying a girl with Down syndrome, he hands the second child over to Caroline without his wife's knowledge. Henry's fateful decision yields grave consequences for his family over the next 20 years.

A young woman with Down Syndrome begins a journey chases her dream of becoming a mechanic, despite being held back by the person she trusts the most.

Two young men form a connection on the swings of their local park.

When Sam splits up with her partner, she is forced to move back into her childhood home with her mother and neurodivergent brother. When depression sinks in, her brother Emmett gets in her face trying to cheer her up and in doing so makes everything worse. But when Emmett is confronted with a situation at a baseball game where he is called a chicken, Sam rises to the challenge to come to his aid and is reminded of what is truly important.

In the 1940s a 40-year-old woman with five healthy children gives birth to a girl with Down's syndrome.

Jess is thrilled to be the surrogate for her best friend and his husband, but when a prenatal test comes back, it creates a moral dilemma that threatens their friendship.

Georges has Down syndrome, living at a mental-institution, Harry is a busy businessman, giving lectures for young aspiring salesmen. He is successful in his business life, but his social life is a disaster since his wife left him and took their two children with her. This weekend his children came by train to meet him, but Harry, working as always, forgot to pick them up. Neither his wife or his children want to see him again and he is driving around on the country roads, anguished and angry. He almost runs over Georges, on the run from the institution since everybody else went home with their parents except him, whose mother is dead. Harry tries to get rid of Georges but he won't leave his new friend. Eventually a special friendship forms between the two of them, a friendship which makes Harry a different person.

Martin Durnley is a young man with an infantilizing mother, resentful stepfather and an institutionalized brother with Down's syndrome. To cope, he retreats into an alternate child personality he calls Georgie. After being caught during a theft attempt at a department store, he befriends a female customer who is sympathetic to him, but his friendship soon turns into obsession.