The plot concerns a war hero who returns home determined to give up his old ways as a crook. Bud Doyle (Milton Sills) is still being hounded by the cops, and both his wife (Marcia Nanon) and a former associate, a dishonest politician, want to do him in.
A man is shipwrecked on a South Seas island, and although he has a fiancee back home, he falls in love with a Polynesian girl. When his fiancee finally finds him and arrives on the island to take him home, she finds out that he refuses to leave the local girl, who is now the mother of his child.
When two men, one from the city the other a trapper and a woman are trapped in a cabin in the Northwoods after a massive snowstorm. Through the winter a silent bitter struggle develops between the men for the hand of the young woman which ends in the treachery of the city man being exposed and the trapper winning the affections of the young woman after a thrilling forest fire.
A young boy aspires to knowledge and higher education but his father, a plain man with narrow goals, is content with an ordinary school education for him and puts him to work despite the principal's protests. The principal even offers the father an opening by which his son could work during the day and attend school at night throughout a season, but the father declines. Disheartened by the life of drudgery, his father’s decision has wrought he travels the wrong road and goes from hopelessness to recklessness, trapped in an unhappy marriage and a life of hopelessness.
Shakespeare Clancy is a jailbird who walks out with a crowd of visitors about the time "Skeeter" Burns, the prison printer, is discharged. Learning that a legacy awaits them in Dodson, the pair depart for the small Western town. Discovering that the bequest consists of a failing county newspaper and a plot of barren land, they hatch a plan to fleece the townspeople by selling shares in a bogus oil well. Problems arise when Clancy falls in love with society editor Alice Whitney. Clancy is conflicted but then they do strike oil! Concluding that his destiny is to be an honest man, Clancy returns to jail to finish serving his term. Slipping into the crowd of visitors, he dons his prison clothes and resumes work as though nothing had happened.
Sato (Sessue Hayakawa) faithfully works for importer James Thornton (James Neill). When the old man dies, he leaves his daughter Mildred (Vivian Martin) in Sato's care. Sato loves the girl, but as he is Japanese he cannot hope to ever marry her (at least not in the racially prejudiced era of the early 1900s). Besides, Mildred loves Harry Maxwell (Tom Forman), who was raised alongside her.
Tim spends his days running with a railroad gang which frustrates his struggling parents. When his father falls ill Tim reluctantly gets a job begrudging being forced into that position, but when events take a tragic turn he realizes the need for him to become a responsible adult.
A young English nobleman is sent to Switzerland by his parents, where he meets a mysterious older woman with whom he has a torrid three-week romance.
Young New York playboy Stephen Winthrop inherits the entire estate of his wealthy Canadian uncle but pays scant attention to it, preferring the "party" life in New York. He is unaware that the family attorney, Frank Garson, has forbidden hunting on the Winthrop lands in Canada, cutting off the livelihoods of the local villagers. Mary Cartier, goddaughter of the village priest, travels to New York to try to get Stephen to change the policy. He returns with her to Canada, sees what's going on, and lifts the ban, then decides to stay in Canada. Mary returns to New York to try to help Garson's abandoned and ill wife and child, but the wife dies, and Mary brings back the small child to Canada. The villagers, mistaking the child for Mary's, are outraged at this "scarlet woman" flaunting her illegitimate child and attempt to drive her out. Complications ensue.
Uncle Sam is mistaken for Marion's uncle Sam.
Chorus girl Peggy Malone marries press agent Jimmy Parsons but faces hardship when her shiftless family moves in, causing Jimmy to fall ill and go West for health. Peggy follows, becomes a film star, and ultimately chooses the now-successful Jimmy over a wealthy suitor, securing their future together.
Barbara Rand is blinded when she leaps through a window to escape an assailant. Her sister, Natalie, reluctantly abandons her fiancé, Ned Gardiner, and marries Oliver Landis, who can provide the money needed for Barbara's operation. Unaware that Oliver was Barbara's attacker, Natalie blames his business partner, Howard Pollard, who was with Barbara on the night she was injured. Natalie holds Howard at gunpoint, but when her husband arrives, he promises to deal with the villain making sure Howard falls to his death. Upon Barbara’s release from the hospital, Oliver tries to blind her once. Natalie threatens him with a pistol, but Oliver wrests it away from her. He then realizes that he can no longer hide his guilt from Natalie or the police and shoots himself. Barbara has been avenged, and Natalie is free to marry Ned.
When Rosamond, a convent girl, discovers that her mother is Baby Brabant, a notorious queen of Petworth's gambling house, her ideals are shattered and she denounces her mother's life.
Jimmy Nevins--once wealthy and now engaged to Doris Standish--is reduced to poverty and jilted by her when he is befriended by Mary Butler, the leader of a gang of crooks.
A gangster running a protection racket gets information that he's about to be prosecuted on income-tax-evasion charges. He hires a man with a photographic memory to memorize his books, then destroys them all so the police won't have any evidence to link him to the racket.
Most mothers are more or less wrong about their children. Mrs. Reed loved her youngest son, Edward, who was a clever rascal, so blindly that her eldest son, Jim, a generous but somewhat stupid boy, did not get his due dose of maternal affection. Jim was always unlucky, while Edward was never short of good clothes and plenty of money to make his pockets ring.
A recently widowed and destitute young mother (Jane Novak) appeals to her wealthy and heartless father-in-law (Robert Edeson) for financial aid. Instead, he convinces her to hand over her new baby to his care so that the child will be brought up with "everything money can buy." Unbeknownst to the grandfather, we learn that there are twin sons and our heroine keeps one baby to raise herself. The narrative jumps ahead to the boy's twenty-first birthday and we see what's become of them. Not surprisingly, the wealthy son has grown up spoiled and greedy while the poor one works hard and loves his mother.
Jack Pickford got his own production company when his sister Mary signed a huge contract with First National, and this was its first product. the story takes place in the Blue Ridge mountains, where the Appersons and the Yartons have an ongoing feud.
Andrew Maxwell is so intent on creating a universal language that he completely neglects his wife, Laurette, and daughter, Ruth. Laurette decides she wants to return to the stage and is encouraged by Charles Prescott, a former suitor. When Maxwell discovers Laurette and Prescott together, he berates her, and she angrily moves out, taking Ruth along with her.
The Isle of Lost Men is one of those lawless tropical island colonies so beloved of adventure-story writers.