Corporate billionaire Edward Cole and working class mechanic Carter Chambers are worlds apart. At a crossroads in their lives, they share a hospital room and discover they have two things in common: a desire to spend the time they have left doing everything they ever wanted to do and an unrealized need to come to terms with who they are. Together they embark on the road trip of a lifetime, becoming friends along the way and learning to live life to the fullest, with insight and humor.
Trucker Rubber Duck and his buddies Pig Pen, Widow Woman and Spider Mike use their CB radios to warn one another of the presence of cops. But conniving Sheriff Wallace is hip to the truckers' tactics, and begins tricking the drivers through his own CB broadcasts. Facing constant harassment from the law, Rubber Duck and his pals use their radios to coordinate a vast convoy and rule the road.
Two middle-aged men embark on a spiritual journey through Californian wine country. One is an unpublished novelist suffering from depression, and the other is only days away from walking down the aisle.
Jake Blues, just released from prison, puts his old band back together to save the Catholic home where he and his brother Elwood were raised.
Determined to gatecrash her ex-lover's funeral on glamorous French hideaway Île de Ré, former Hollywood siren Helen escapes her London retirement home with help of repressed English housewife Priscilla and they hit the road together in a race to get to the funeral on time.
To find his therapy dog, a 17-year-old escapes from juvie and embarks on a journey of reconnection with his brother and grandmother through Cantabria.
Three years after Mike bowed out of the stripper life at the top of his game, he and the remaining Kings of Tampa hit the road to Myrtle Beach to put on one last blow-out performance.
Lloyd and Harry are two men whose stupidity is really indescribable. When Mary, a beautiful woman, loses an important suitcase with money before she leaves for Aspen, the two friends (who have found the suitcase) decide to return it to her. After some "adventures" they finally get to Aspen where, using the lost money they live it up and fight for Mary's heart.
A naive Canadian barber who knows US popular culture inside and out meets a flamboyant roadie who needs someone to drive her and her "brother's" corpse from Thunder Bay, Ontario to New Orleans. Chaos ensues after the barber agrees to drive her, the corpse, and the drugs stashed within all the way.
When Erik Stifler realizes that he's the only Stifler family member who might graduate high school a virgin, he decides to live up to his legacy. After some well-meaning advice from Jim's dad, Erik's ready to take his chances at the annual and infamous Naked Mile race, where his devoted friends and some uninhibited sorority girls will create the most outrageous weekend ever.
With the help of an irreverent young sidekick, a bank robber gets his old gang back together to organise a daring new heist.
After breaking up with her girlfriend, a nightclub singer, Jane, answers a personal ad from Robin, a real estate agent with AIDS, seeking a cross-country travel partner. On their journey from New York City to Los Angeles, the two stop by Pittsburgh to pick up Jane's friend Holly, who is trying to escape an abusive relationship. With three distinct personalities, the women must overcome their differences to help one another.
Single mom Laura, along with her awkward 14 year-old son Henry is forced to drive Jack, her estranged, care-free pot dealing father across country after he's kicked out of yet another nursing home.
In turn-of-the-century Mississippi, an 11-year-old boy comes of age as two mischievous adult friends talk him into sneaking the family car out for a trip to Memphis and a series of adventures.
Jerry Welbach, a reluctant bagman, has been given two ultimatums: The first is from his mob boss to travel to Mexico and retrieve a priceless antique pistol, known as "the Mexican"... or suffer the consequences. The second is from his girlfriend Samantha to end his association with the mob. Jerry figures alive and in trouble with Samantha is better than the more permanent alternative, so he heads south of the border.
Architect Mark Wallace and his wife, Joanna, travel to France to meet with an affluent client. While there, they reflect on their first decade of marriage -- memories of when they first met, of courtship, and of road trips through the French countryside. As flirtation and playful quarreling turn to boredom with the banality of married life, the Wallaces struggle to rekindle their passion, while mutual infidelity threatens to tear them apart.
Married small-time crooks Lou-Jean and Clovis Poplin lose their baby to the state of Texas and resolve to do whatever it takes to get him back. Lou-Jean gets Clovis out of jail, and the two steal their son from his foster home, in addition to taking a highway patrolman hostage. As a massive dragnet starts to pursue them across Texas, the couple become unlikely folk heroes and even start to bond with the captive policeman.
When his mother dies, a teenager takes a road-trip in a stolen car to find his long-lost brother. Along the way he discovers a profound connection with the car-owner and with himself as well.
A road trip to Los Angeles inadvertently leads a young man from Wyoming into a wild maze of psychotic hit-men, racy women, jewel thieves and a salsa band.
Gib, a beer-guzzling slob, and Alison, an uptight Ivy-Leaguer, are an unlikely duo stuck together on a cross-country trip during Christmas break. At first they get on each other's nerves but, as time passes, they find their divergent natures complement each other. Now they need to realize what they've already found before it's too late.