The Bowery Boys join the Navy to catch some crooks who are posing as sailors.
The boys buy a uranium mine out west, but when they get there they find that it's pretty much worthless. However, the local badmen are distrustful of these new strangers, and when they mistakenly get the impression that the mine is loaded with uranium, they hatch a scheme to get rid of the boys and take over the mine.
An electric shock enables Satch to predict numbers, so the Bowery Boys are off to Las Vegas to win enough money at the roulette wheels to let their landlady buy an apartment building. Witnessing his winning streak, some gangsters decide to move in and find out his "system" for beating the odds.
Slip and Sach are in the sidewalk star-gazing business when they see a murder committed in a room at the El Royale Hotel.
Dr. Tom O'Hara takes over a public clinic in New York's desperately poor Bowery section. Boy gangleader Sock Dolan resents Tom's interference in moving Sock's kid brother to a hospital, because Sock blames hospitals for his mother's death. Sock helps racketeer J.R. Mason sell food to the clinic, unaware that Mason sells cheap and often tainted food. When a number of patients, including Sock's brother, become ill from food poisoning, Sock is kidnapped by Mason to keep him silent. Dr. O'Hara must find a way to rescue Sock and stop Mason's contamination of hospital food supplies.
After Slip is drafted into the Marines, the rest of the gang volunteers so they can be with him. Sach discovers that the colonel knew his father and he is promoted. During a drill that he is putting the rest of the gang through, they find a soldier left for dead on the side of the road. Slip discovers a playing card next to the marine and traces it to Jolly Joe Johnson's gambling house. They suspect that the gambling house is cheating and set out to uncover the proof.
When one of the Boys agrees to be hypnotized, he discovers he led a past life in the 1600s as a British tax collector.
Sach and the gang baby-sit a bratty TV star.
Slip and the gang (Bowery Boys) foil foes of the exiled, incognito king of Truania (Sig Ruman).
Sach and the gang (Bowery Boys) find stashed cash in an old farmhouse apparently haunted.
Sach and the gang (Bowery Boys) fool Nazis and a sultan in North Africa.
The Bowery Boys come to the rescue when a corrupt taxi company puts the squeeze on several independent drivers.
Slip, Sach and the gang (Bowery Boys) think an air-raid test is for real and join the Army.
The Bowery Boys (Bowery Boys) open a nightclub after Sach has his tonsils out and wakes up with a singing voice.
One of the Bowery Boys gains superhuman strength, and he cashes in by becoming a pro wrestler.
While working in a laundromat, the boys find a baby hidden among the linen. They soon find out that the baby, who is the heir to a fortune, has been abandoned by his mother so that her two evil aunts can't cheat her and the baby out of the inheritance. The boys determine to help the woman claim her baby's rightful inheritance from her aunts, who have hired gangsters to find and eliminate the girl, the baby and anyone who helps them.
After being punched in the nose, Sach finds out that he has the ability to read minds. Slip and the gang start up a detective agency try to cash in on Sach's new powers.
Slip and Sach take the rap for a robbery they did not commit in order to uncover the real robbers, whom they suspect are led by a convict who gives orders to his gang outside via a short-wave radio stashed somewhere in the prison.
When Sach eats too much sugar, he goes into a trance whereby he's able to predict the future. Slip tries to make some money off of Sach by using him as a fortune teller in a carnival, until a mad scientist kidnaps Sach to use him in an intelligence-switching experiment with a monster.
Slip and Sach (Bowery Boys) go to prison to help a reporter with a story.