Slip and Sach are working for a local newspaper as a reporter and photographer, respectively. Slip wants to get the goods on a local gambling ring that is fixing sporting events, so he and Sach go undercover to expose the ring.
In order to be able to get the names of winning horses at the track, Sach agrees to sell his soul to the devil.
The Bowery Boys find a lamp that has strange magic powers.
A ghost helps the Bowery Boys capture a gang of crooks led by a mad doctor.
Slip has entered the Boys' rattletrap car in a souped-up jalopy race, but has no chance of winning until Satch, with the aid of a scientist acquaintance, comes up with a chemical concoction that acts as a super-fuel; but a rival entrant in the race learns of this and tries to get the formula for himself.
Sach is the exact double of a famous French scientist who has invented a powerful rocket fuel. Enemy agents, mistaking Sach for the scientist, attempt to kidnap him and get the formula for the fuel.
The Bowery Boys join the Navy to catch some crooks who are posing as sailors.
The Bowery Boys come to the rescue when a corrupt taxi company puts the squeeze on several independent drivers.
Slip and Sach go to prison to help a reporter with a story.
One of the Bowery Boys gains superhuman strength, and he cashes in by becoming a pro wrestler.
An overambitious shutterbug almost gets his lights put out permanently when he decides to snap a picture of a mob boss.
Sach learns that he has inherited a farm in rural hillbilly country, and when he and the Boys arrive there, they find themselves mixed up with a hillbilly clan named Smith who'll shoot anybody named Jones, plus a gang of bank robbers.
When a cold medicine causes Sach to be able to smell diamonds, he and the rest of the Bowery Boys are induced by a diamond dealer to accompany him to Darkest Africa in search of a legendary cache of them.
Slip gets fired from his job at a construction company for decking his boss. His sister, who got him a job at the company, is angry with him. Slip manages to get a job with the District Attorney serving warrants, as does Sach. Through his job, Slip finds out that all is not quite kosher at his old construction company, and that his sister may be in danger.
Sach receives news that he is the heir to the Terwilliger Debussy Jones fortune. Accompanied by his pal Slip, he arrives at the Jones mansion to review the legal papers needed for him to claim his new fortune. However, Sach and Slip discover that the rightful heir, the young Terwilliger III, is being cheated out of his inheritance by the miscreant duo of Stuyvesant Jones and Clarissa. Sach and Slip, with the help of their fellow Bowery Boys, save the day and restore the heir’s inheritance.
Slip and Sach are working as cleaners in a high rise building. They enter an office to clean it when a messenger hears them use Slip's given name, Terrance Mahoney. The messenger has a letter for "Terrance Mahonoey, Esq." and mistakenly delivers it to Slip. The letter informs Slip that he has inherited a mansion in Long Island. The boys then make their way to the mansion and find that it is inhabited by diamond smugglers. The real owner of the house shows up and helps save the day and defeat the smugglers and gives the boys the house as a reward.
Sach just lost his job as an assistant to a private detective, but he wasn't paid. Slip goes with him down to the detective's office to demand payment, but finds the office empty. A woman enters the office and mistakes Slip for the detective and convinces him to take on a case to find her sister after offering a $50 retainer.
Slip and Sach's boss, David J. Thurston, has allegedly committed suicide. Slip finds a book of matches with the name of a local nightclub on his boss' desk and finds out from Gabe that a gambling casino is being run out of it. Slip comes to the conclusion that the club had something to do with his boss' death and sets out to find his murderer. The boys get jobs at the club and Louie poses as a rich cattlemen as they gather the information to convict the murderers.
The boys are working at the local boxing arena where their friend, Jimmy Higgins, is boxing. During a crooked match Jimmy is killed. The boys seek out his older brother, Johnny, a former boxer who gave up the sport rather than go crooked, and help train him to get back in the ring. They try to get him a shot at the title, and when they do the same crooked gangsters that were behind Jimmy's death try to get Johnny to take a dive.
Slip and correspondence school pilot Sach, go to an air base to help a pal out...but find themselves in when they mistakenly sign enlistment forms. Can the Air Force turn these dodos into eagles? The guys may be airborne airheads, But just watch them find a way to ground a spy network that's infiltrated the base.