Andy Panda and his dog, Milo, share their house with an obnoxious mouse who enjoys tormenting the two above anything else.
An archaeologist at a museum scolds his small, silent dog, Shep, for supposedly removing a bone belonging to a dinosaur skeleton and orders Shep to bring the bone back, but Shep finds that the place where he buried his most recent bone has been dug up and a bulldog is walking away with the bone in his mouth. Shep chases the bulldog with intent of retrieving the bone, and so begins a battle of wits between Shep and the bulldog.
On a cold winter's day, a stray dog is looking for shelter, then finds and sneaks into a cabin with an open fireplace and a cozy bed. But he has a stinky rival for occupancy of the cabin - a skunk.
Daffy Duck is working as a babysitter for the Acme Baby Sitting Agency. While he's sitting on a chicken egg, it hatches. The chick decides Daffy is a stranger and he should have nothing to do with him, so flees. Daffy has to catch it.
Two polite twin gophers raid a vegetable patch guarded by a rather smug dog, whose various unsuccessful schemes to nullify the crafty and modest gophers involve a female gopher disguise, a hand grenade, and a carrot stuffed with TNT.
Striving to be like all the high-class dogs in their fine coats, a little hairless pooch borrows a black and white fur coat of her owner, not realizing it makes her appear to be a skunk. Once she has it on, she finds everyone fleeing from her - everyone, that is, except for the amorous Pepé Le Pew.
The city is rounding up all unlicensed dogs. Spike has a license. So does Tyke. An unlicensed stray steals Tyke's license; Tyke gets collared and the chase is on.
Boston Quackie (Daffy Duck) is an American agent in Paris assigned to guard the valuable secret contents of a briefcase. A man in a green hat steals the briefcase and leads Quackie on a chase aboard the Cloak and Dagger Express.
Jack's mother throws Jack's magic beans outside under Sylvester Cat's sleeping box, and the cat is whisked to the world above, where he finds a huge Tweety Bird in the castle of the legendary Giant.
Exhausted traveler Porky Pig drives into a town looking for a hotel. He is delighted to find one with a 10 cents per-night fee. Unfortunately, its manager is Daffy Duck.
Lady, a golden cocker spaniel, meets up with a mongrel dog who calls himself the Tramp. He is obviously from the wrong side of town, but happenings at Lady's home make her decide to travel with him for a while.
When Ben Wrightman, a young teacher, begins dating pretty businesswoman Lindsey Meeks, the two don't seem to have a lot of the same interests, but they fall in love, regardless. Their romance goes well until baseball season begins, and Lindsey soon realizes that Ben is completely obsessed with the Boston Red Sox. Though she tries to understand Ben's passionate team loyalty, eventually it threatens to end their otherwise happy relationship.
Sylvester's carnivorous pursuit of Tweety Bird continues, winding up the cat's spirit in Hell, where he meets a satanic bulldog.
A lip-smacking weasel invades the barnyard of Foghorn Leghorn and his usual canine foe, and Foghorn is quite willing to put baby chicks in danger of being taken by the weasel so long as it makes the dog appear to be failing his job of guarding the chicks.
Porky Pig regrets picking up a hitchhiking Daffy Duck, whose anarchic driving habits forced on Porky result in the two being apprehended.
Two polite gophers are in their underground home, playing gin, when a dog buries his bone right on top of them. They try to negotiate with the dog so that he will bury the bone elsewhere. But the dog refuses to be cooperative.
After listening to one of his favorite radio programs, Porky Pig receives a grand prize from the station. Out of the gift box pops Daffy Duck, who insists on living in Porky's house.
Porky and his dog, Streamline, plant a large garden. The neighbor chickens see the garden as one big buffet/cafeteria.
Popeye brings his magical dog, The Jeep, over to see Olive and Swee'pea, just as the tyke has escaped from his crib. The Jeep leads Popeye on a merry chase looking for Swee'pea.
A series of gags hung on a football game.