The Doctor and Leela must catch a killer on a vast mining ship run by robots and humans.
The cursed island of Fang Rock off the south coast of England is a place of rumour and tales of beasts from the sea. Three lighthouse men at the turn of the century face their fears when something comes from the sea to bring death to all it touches.
A three-man rocket crew are nearly done with their mission to Titan Base until a course change puts the rocket in the path of a strange cloud in space. By the time they arrive, they have come under the control of a sentient virus which threatens the galaxy. When the TARDIS picks up an emergency message, it flies into the cloud, infecting the Doctor. To save himself and others, he must undertake a dangerous journey.
The present day: just as the Fourth Doctor and Leela arrive in Fetchborough, England, Professor Fendelman prepares to experiment on a fossilized skull which science says should not exist. The skull is actually an artefact of the Fendahl, a god-like being who feeds on the life force of others. It has begun to awaken and kill. Worse yet, others seek to exploit the Fendahl's dreadful power.
Far in the distant future, Earth has become uninhabitable, forcing Mankind to colonise first Mars and then Pluto. No longer the coldest planet in the solar system, Pluto is now warmed by artificial suns. The Doctor, Leela and K9 arrive to discover the exploitation of the Megropolis people by the ruling elite, lead by the Collector. Deep in the Undercity, a small group of revolutionaries plot to overthrow the company and the Doctor is forced to fight the oppression of the people using Fire against Fire...
On the edge of the universe, the Doctor, Leela and K9 encounter a Minyan ship on an epic quest to find their race banks... but their people have encountered the Time Lords before...
The Doctor and his companions arrive on a spaceship headed for Earth, populated by natives of Earth from various different eras and commanded by the leaders of the Urbankan race. What are the Urbankans' intentions when they reach Earth?
The TARDIS lands on the idyllic jungle world of Deva Loka, which is being surveyed for possible Earth colonisation. Deva Loka is already home to a race of apparent savages, however: a mysterious people with strange powers which have mentally unbalanced the members of the expedition. To make matters worse, an ancient enemy of the natives known as the Mara is intent upon revenge, and latches onto Tegan's mind as its bridgehead to victory.
In 17th century England, the Doctor and itinerant thespian Richard Mace uncover a plot by a crew of criminal Terileptils to wipe out humanity.
The TARDIS arrives in 1925 England where the Doctor ends up playing in a local cricket match due to a case of mistaken identity. The travellers accept an invitation to a masked fancy dress ball, but events take on a more sinister tone as murders are perpetrated at the country home of their host, Lord Charles Cranleigh.
While investigating a vanishing Concorde at Heathrow Airport, the Doctor and his companions are thrown millions of years back in time, when a mysterious alien called Kalid is trying to control the ancient powers of the Xeraphin.
Omega, an ancient Time Lord made of pure anti-matter, once defeated by the Doctor, is plotting to cross over into this dimension by bonding with the Doctor. Meanwhile, the disappearance of a man in Amsterdam piques the curiosity of his cousin, Tegan, who previously left the Doctor at Heathrow Airport and now finds herself at Omega's mercy. Fearing total destruction from the collision of matter and antimatter, the Time Lords recall the Doctor to Gallifrey to undertake the only viable solution: executing him!
Tegan falls once more under the influence of the Mara and directs the TARDIS to the planet Manussa. There, the Federator's son Lon and his mother Tanha are preparing for a ceremony to celebrate the banishment of the Mara five hundred years earlier. The Mara takes control of Lon and uses him and Tegan to obtain from Ambril, the Director of Historical Research, the 'Great Crystal' - the large blue stone that originally brought it into being by focusing energy from the minds of the planet's one-time inhabitants. The Mara now plans to use the crystal during the ceremony to bring about its return to corporeal existence.
A warp ellipse draws the TARDIS off course. The Fifth Doctor's companions are separated from him not in space, but in time, and he has to deal with a treacherous schoolboy named Turlough. But why does the Doctor's old friend, the Brigadier, not remember him at all?
The TARDIS attaches itself to a space liner after Turlough, still under the Black Guardian's influence, damages its controls. The Doctor and Nyssa meet two space pirates, Kari and Olvir, who have come on board the liner in search of plunder, while Tegan and Turlough get lost in the infrastructure. The liner docks with what appears to be a hulk floating in space. This is Terminus, which claims to offer a cure for Lazar's disease. It is crewed by armoured slave workers, the Vanir. The cure is administered by a huge, dog-like creature known as the Garm. Nyssa, who has contracted the disease from sufferers transported aboard the liner, discovers that the cure - involving exposure to radiation - does actually work.
The Doctor and a newly-regenerated Romana arrive on Skaro to find that the Daleks, locked in a war with the robotic Movellans, have returned to retrieve their buried creator Davros.
The Doctor and Romana follow a distress signal which leads to the jungle planet Chloris, whose ruthless ruler Lady Adrasta harbors a deadly creature in a pit.
A freak accident leaves two dangerously unstable spacecraft locked together, and a horde of monsters unleashed on their passengers.
Romana fancies a proper holiday and convinces the Doctor to visit the leisure planet Argolis, where a takeover by the Argolins' historic enemy is underway.
In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.