Tom accompanies his owner, Clint Clobber, who has severe anger management issues, on a fishing trip.
This cartoon opens with a narrator introducing the ancient Greek Acropolis, describing its wealth and beautiful architecture. Tom is depicted as one of these inhabitants, an alley cat who lives in the shadows of Athens searching for food.
Tom's owner, Clint Clobber, is grilling steaks in his backyard. The steak's scent reaches Jerry, who is aroused by it and is led to the steak.
Jerry, tired of Tom's repeated attempts to kill him, leaves the house to join a space program. Tom tries to convince Jerry to stay, but to no avail.
Tom and Jerry are sleeping outside during the day when a yellow bird wearing a red helmet lands on Tom, waking him up. Although the bird brushes Tom's torso off and reacts politely like "pardon me", Tom goes after the bird, catches it, and proceeds to beat it up.
While chasing Jerry around a dock, Tom sees and instantly falls in love with a female cat. The female cat appears to return Tom's interest, so Tom sneaks aboard the ship the female cat and her owner have just boarded. Jerry follows Tom onto the boat and proceeds to interfere with Tom's subsequent flirtations.
In a 19th century fishing harbor, the captain of the Komquot is obsessed with catching the great white whale Dicky Moe. His obsession unnerves his crew so badly that they all desert the ship. Shortly afterward, the captain finds Tom searching for food in the harbor, knocks him out, and takes him aboard. Tom believes at first that he is going on a cruise, but the captain soon puts him to work scrubbing the deck.
When Jerry rustles cheese from the Dry Gulch General Store, Sheriff Mutt Dillin hires Tom, the fastest trap in the West.
Tom joins his owner on a hunting safari in Kenya. Jerry has hidden himself in the Clint's luggage, and Tom quickly sees him and attempts to get rid of him.
On a snowy night in the city, Jerry is comfortably asleep in his hole inside a penthouse, while Tom tries to keep from freezing to death in the alley below.
Jerry runs into the Metropolitan Opera, trying to evade Tom.
Tom, famous baritone Signor Thomasino Catti-Cazzaza, enthralls a concert audience with his rendition of "Largo al factotum", from Rossini's "Il Barbiere di Siviglia", while Jerry strives for sleep under the stage.
Jerry mixes and drinks a high-acceleration potion which renders him so fast that he eats all of Tom's food before the bewildered cat can even see him.
When a bulldog tells Jerry to "just whistle" any time that he needs him, Tom's in for big trouble until he puts earmuffs on the mutt.
Waif mouse Jerry, encrusted with snow, peers through a warmly lit window at Tom asleep by the fire in a room full of cheese.
Jerry heads out to his night job: drummer for an all-mouse rock band in the basement of a high-rise. They are loud enough to wake up Tom, despite his attempts to block the noise. Tom's attempts keep running him afoul of a rather mean-tempered dog.
Tom chases Jerry into a fish cannery; they get sealed into cans. Tom breaks out, but falls off a pier as the cans roll under him. A shark chases him out of the water; Tom drops an anchor on the shark. Meanwhile, Jerry has been hopping in his can; Tom opens it, and puts his finger in, which Jerry bites. Jerry tricks Tom into falling off the end of another pier, and right into the shark's path again. The shark manages to get Tom into a very precarious position, barely holding the jaws apart. Jerry takes pity, and dumps a shaker full of pepper into the shark, which ends up on the processing line and stuffed into a huge can. Tom is unrepentant, so Jerry tricks him with a fake shark fin.
Jerry uses a robot mouse to snatch a sample from a lunar cheese mine being mined by robots; Tom gives chase with a robot cat.
Tom and Jerry are taking a cruise when Tom decides to go surfing. He has problems with a shark and a rather tenacious starfish.
Tom has a nightmare of being pounded by a giant dog. Jerry lures Tom into a series of encounters with a miniature vicious bulldog.