Tom has amnesia and believes he's a mouse. Jerry, finding him more obnoxious as a fellow rodent than as a cat, seeks to cure him with a blow to the head.
Tom pretends to have a cold in order to trick Mammy into letting him stay inside for the night. Jerry tricks Tom by making him think he really is sick - with the measles.
Jerry's eccentric uncle, Pecos, a Texan mouse, comes to spend the night with him before his musical performance on television the next day. He decides to rehearse with his guitar for the performance but each time he plays, one of his guitar strings snaps off. Fortunately, he is able to replace them by plucking off one of Tom's whiskers each time. Tom is rather reluctant about this and tries to hide to protect his whiskers from Uncle Pecos.
The couple that owns Tom and Spike decides they can't afford to keep both. They agree that the first one to catch the mouse can stay - bad news for Jerry.
Jerry and his diapered little mouse friend flood the kitchen, then use the freezer to turn it into a skating rink. Even though Tom finds a pair of ice skates, the mice have no problem outmaneuvering him.
A moment after a bottle of white shoe polish pours on Jerry, Tom hears on the radio that a white mouse, having swallowed an explosive, has escaped from an experimental laboratory and that slightest jar of the mouse could cause it to explode and blow up the entire city. It is then that Tom notices now-white Jerry and concludes it's the escapee.
Tom sells Jerry to a local pet store that's buying white mice. Yes, Jerry's brown, but a little paint fixes that.
Tom inherits $1,000,000 from an eccentric aunt on the condition that he not harm any living thing - even a mouse. And guess which mouse keeps following him around and pointing this out to him?
When a bulldog threatens Tom to keep away from his puppy, Jerry realizes that sticking close to the boy is the best way to keep away his feline tormentor. But Tom is not about to let the mouse evade him so easily.
Jerry Mouse gets tired of living the country life and decides to head to the big city. However, the experience doesn't turn out quite like Jerry had expected.
Tom settles in for a day at the beach with his sweety, accidentally ruining Jerry's day. Meanwhile, Tom's girl is paying more attention to the bodybuilders than to Tom.
A Spanish cat is more interested in playing flamenco guitar than trying to catch the mouse El Magnifico (Jerry). Tom arrives from the States with world champion mouse-catching credentials to have a go.
Tom chases Jerry through the streets of Naples; they meet a local mouse who recognizes them from their cartoons and shows them around. Meanwhile, some local dogs are shadowing them.
Tom, complete with mortarboard, is teaching a kitten the basics: "cats chase mice." But Jerry keeps subverting this lesson at every opportunity.
Spike is taking his son on a picnic. Jerry keeps hiding in the basket, so Tom keeps disrupting the picnic while chasing him.
Jerry rescues a bag of puppies from the river. Most of them run away as soon as Jerry releases them, but one stays behind. Jerry tries to get rid of it, but ultimately takes pity and invites the frisky pup inside, where he has to hide it from Tom, who keeps throwing it out.
Tom's being especially lazy, which makes it even easier for Mammy to toss him out when her new mouse-catching robot cat, Mechano, arrives. Mechano is frighteningly efficient, foiling several attempts by Jerry. Jerry turns this efficiency against him by unleashing several mechanical mice; the zealous robot makes a shambles of the house, and finally itself, in the process of chasing them down. Tom is welcomed back, but at the last moment, a key part of the robot had gone down Tom's throat; Jerry activates it, and sends Tom chasing after one of the wind-up mice.
Tom and Jerry are in a cabin in the wild west. Jerry's rustling food, so Tom's owner won't let him eat until he's gotten rid of Jerry.
Tom has been out late carousing with his chums. When he gets home, Mammy won't take any excuses, and insists he stay awake; Jerry, overhearing, thus tries a number of schemes to get Tom to sleep.
Spike has just washed his pup. Tom and Jerry's chase knocks him into a mud puddle. Spike makes Tom clean him up again and promise to keep him clean which of course is Jerry's opening to get Tom in trouble.