After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.
When an asteroid threatens to collide with Earth, NASA honcho Dan Truman determines the only way to stop it is to drill into its surface and detonate a nuclear bomb. This leads him to renowned driller Harry Stamper, who agrees to helm the dangerous space mission provided he can bring along his own hotshot crew. Among them is the cocksure A.J. who Harry thinks isn't good enough for his daughter, until the mission proves otherwise.
God contacts Junior Congressman Evan Baxter and tells him to build an ark in preparation for a great flood.
Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.
An irritable marketing executive, Neal Page, is heading home to Chicago for Thanksgiving when a number of delays force him to travel with a well meaning but overbearing shower curtain ring salesman, Del Griffith.
Dedicated environmental lawyer Lucy Kelson goes to work for billionaire George Wade as part of a deal to preserve a community center. Indecisive and weak-willed George grows dependent on Lucy's guidance on everything from legal matters to clothing. Exasperated, Lucy gives notice and picks Harvard graduate June Carter as her replacement. As Lucy's time at the firm nears an end, she grows jealous of June and has second thoughts about leaving George.
Dutch coach Thomas Rongen attempts the nearly impossible task of turning the American Samoa soccer team from perennial losers into winners.
An actor who is considering the role of a supermarket manager arrives at a grocery store on the outskirts of Los Angeles to do some field research. He subsequently becomes stranded, without a car or cell phone, and accepts a ride home with Scarlet, a cashier who is about to interview for a new job. The actor rediscovers the essence of his craft while helping Scarlet gain the confidence she needs to change her life.
Angela de Marco is fed up with her gangster husband's line of work and wants no part of the crime world. When her husband is killed for having an affair with the mistress of mob boss Tony "The Tiger" Russo, Angela and her son depart for New York City to make a fresh start. Unfortunately, Tony has set his sights upon Angela -- and so has an undercover FBI agent looking to use her to bust Tony.
Molly Mahoney is the awkward and insecure manager of Mr. Magorium's Wonder Emporium—the strangest, most fantastic and most wonderful toy store in the world. After Mr. Magorium bequeaths the store to her, a dark and ominous change begins to take over the once-remarkable Emporium.
Convenience and video store clerks Dante and Randal are sharp-witted, potty-mouthed and bored out of their minds. So in between needling customers, the counter jockeys play hockey on the roof, visit a funeral home and deal with their love lives.
Both dumped by their girlfriends, two best friends seek refuge in the local mall. Eventually, they decide to try and win back their significant others and take care of their respective nemeses.
A calamity at Dante and Randall's shops sends them looking for new horizons - but they ultimately settle at Mooby's, a fictional Disney-McDonald's-style fast-food empire.
Buck Russell, a lovable but slovenly bachelor, suddenly becomes the temporary caretaker of his nephew and nieces after a family emergency. His freewheeling attitude soon causes tension with his older niece Tia, loyal girlfriend Chanice, and just about everyone else who crosses his path.
A faulty computer causes a passenger space shuttle to head straight for the sun, and man-with-a-past Ted Striker must save the day and get the shuttle back on track – again – all the while trying to patch up his relationship with Elaine.
Two quirky, cynical teenaged girls try to figure out what to do with their lives after high school graduation. After they play a prank on an eccentric, middle aged record collector, one of them befriends him, which causes a rift in the girls’ friendship.
Chaos reigns at the natural history museum when night watchman Larry Daley accidentally stirs up an ancient curse, awakening Attila the Hun, an army of gladiators, a Tyrannosaurus rex and other exhibits.
When maladjusted orphan Jesse vandalizes a theme park, he is placed with foster parents and must work at the park to make amends. There he meets Willy, a young Orca whale who has been separated from his family. Sensing kinship, they form a bond and, with the help of kindly whale trainer Rae Lindley, develop a routine of tricks. However, greedy park owner Dial soon catches wind of the duo and makes plans to profit from them.
After being held captive in an Afghan cave, billionaire engineer Tony Stark creates a unique weaponized suit of armor to fight evil.
Las Vegas showroom magician Cris Johnson has a secret which torments him: he can see a few minutes into the future. Sick of the examinations he underwent as a child and the interest of the government and medical establishment in his power, he lies low under an assumed name in Vegas, performing cheap tricks and living off small-time gambling "winnings." But when a terrorist group threatens to detonate a nuclear device in Los Angeles, government agent Callie Ferris must use all her wiles to capture Cris and convince him to help her stop the cataclysm.