The cat of the house has its nap interrupted by two playing puppies, which sets off a chain of events.
Pepe Le Pew, the eternally amorous skunk, is in Paris, where his stench sends a female cat upward to hit a freshly painted flagpole, which puts a white stripe on her back and causes Pepe to think she also is a skunk. He lustfully pursues her into the Louvre art gallery.
When Jerry rustles cheese from the Dry Gulch General Store, Sheriff Mutt Dillin hires Tom, the fastest trap in the West.
On a snowy night in the city, Jerry is comfortably asleep in his hole inside a penthouse, while Tom tries to keep from freezing to death in the alley below.
Tom, famous baritone Signor Thomasino Catti-Cazzaza, enthralls a concert audience with his rendition of "Largo al factotum", from Rossini's "Il Barbiere di Siviglia", while Jerry strives for sleep under the stage.
Waif mouse Jerry, encrusted with snow, peers through a warmly lit window at Tom asleep by the fire in a room full of cheese.
Tom enjoys the role of top cat until an adorable red-and-white-haired kitten is brought into the house of a young blonde woman.
An alley cat attempts to steal the goldfish Andy Panda just bought from a pet shop, but the fish proves too clever for him.
Mickey, Minnie, Horace Horsecollar, and Clarabelle Cow go on a musical wagon ride until Peg-Leg Pete tries to run them off the road.
Sniffles the mouse and his friend the Bookworm decide to take up egg collecting, setting their eyes upon a big barn owl egg. But the big barn owl isn't so hot on the idea.
Sniffles the mouse is in the country for a restful vacation of fresh air, enjoyment of nature, and peace and quiet.
Sniffles the mouse's friends talk him into putting a bell around the neck of the troublesome house cat.
Sniffles the mouse and his friend the Bookworm try to evade a cat in a the toy department of Lacy's department store.
Jerry keeps sleepwalking and doing things unknowingly to Tom. He becomes aware of this and tries to stay awake.
An inebriated mouse with a throbbing head takes a priceless diamond, thinking it's a soothing piece of ice. Two policemen, one of them a lunkhead, are assigned to recover the missing jewel.
In the French Alps, an out-of-control street-painter's wagon sprays a stripe of white paint atop a female cat's back. Enter Pepé Le Pew.
Sylvester Cat and a tough bulldog escape, chained together, from a transport vehicle headed for the city animal pound and make like convicts on the lam.
Jerry is paid a visit by a look-alike magician.
Tom chases Jerry through city streets, gets run over by a streetcar (twice), and follows Jerry into a department store. In the toy department, they have some fun with radio-controlled cars and a collection of mouse dolls. They move on to sporting goods, where Jerry manages to combine table tennis with croquet.
Exhausted traveler Porky Pig drives into a town looking for a hotel. He is delighted to find one with a 10 cents per-night fee. Unfortunately, its manager is Daffy Duck.