"As everyone knows," the narrator begins, "goldfish must have water... and cats hate water." And so it goes.
Porky can't sleep because mice demolish his plates. A cat offers help and gets the mice out, but invites some friends so Porky still can't sleep.
Andy Panda and his dog, Milo, share their house with an obnoxious mouse who enjoys tormenting the two above anything else.
Take-off on the "Duffy's Tavern" radio program, with tough-guy Eddie G. Robincat demanding a meal of mouse knuckles, "of which we ain't got none," waiter Filligan informs his absentee boss on the phone. To fill the plate, Filligan then tries to catch the blabbermouth mouse, Sniffles.
Snowbound in a remote cabin, two starving men begin visualizing each other as food. When salesman Daffy Duck calls at their door, it doesn't take long before the men set their minds on having Daffy as their dinner.
Mickey, Minnie, Horace Horsecollar, and Clarabelle Cow go on a musical wagon ride until Peg-Leg Pete tries to run them off the road.
Sylvester's carnivorous pursuit of Tweety Bird continues, winding up the cat's spirit in Hell, where he meets a satanic bulldog.
Sylvester Cat accepts a position as mouse-catcher on a ship, and his son, Junior, accompanies him. They encounter baby kangaroo Hippety Hopper being shipped from Australia and, as usual, mistake Hippety for a giant mouse.
Barney, outraged by his neighbor William Wildcat spanking his son, borrows the lad to try applying child psychology. But the boy's grasp of psychology (and explosives) is much better than Barney's.
A drunken stork delivers a baby mouse to the home of Mr. and Mrs. Sylvester Cat. Sylvester is about to eat the little rodent when it calls him Daddy. Touched, Sylvester adopts the mouse as his son - which, distressingly, attracts every hungry cat in the neighborhood to his door!
Popeye's snoring is keeping his resident mouse awake. The mouse fights back.
After driving the Foreign Legionnaires from their fort with his aroma, lovesick skunk Pepe falls for the camp mascot, a cat who's accidentally gotten a white stripe painted down her back.
Sylvester Cat pays a visit to a closed-to-business circus and finds Tweety Bird in one of the cages. Tweety escapes and a mad chase ensues. Meanwhile, Sylvester must flee from an uncaged lion he angered earlier.
Sniffles the mouse and his friend the Bookworm decide to take up egg collecting, setting their eyes upon a big barn owl egg. But the big barn owl isn't so hot on the idea.
Sniffles the mouse is in the country for a restful vacation of fresh air, enjoyment of nature, and peace and quiet.
A cat (not Sylvester) tries to capture a little canary bird (not Tweety), and not get caught by protective Granny.
When his car breaks down out in the country, Sniffles the mouse takes shelter in an old mill, where he meets up with "Batty," a non-stop-talking little bat who later save Sniffles from a hungry cat.
Sniffles the mouse and his friend the Bookworm try to evade a cat in a the toy department of Lacy's department store.
The mice are on the loose after hours in a doctor's office, playing with the various pieces of medical apparatus. Susie Mouse is caged for research until her lover Johnnie frees her. A mouse orchestra plays a swinging wedding song. But throughout, a cat is stalking...
Sniffles the mouse, in his first appearance in a Warner Bros. cartoon, goes to a drugstore and gets drunk on a cold remedy, then befriends an electric razor and gets it drunk as well.