Residents of a small frontier town take up arms when vigilantes try to block a railroad right-of-way.
In a cantina across the border, Bob Hamlin shoots a man that threatens his friend. He and his pals escape but return that night for the dance as Bob is attracted to Conchita. Running once more from the Rurales, Bob takes Conchita. They escape again only to find themselves pinned down when Buck and his gang of horse thieves attack.
Carl Beldon has disappeared and the Trail Blazers have been sent to investigate. Arriving in town, they find that 'Honest John' controls everything. He even prints his own money. He also has a gang and they set out to finish off the heroes.
Narrowly escaping death, outlaw Johnny Madrid goes on the run with the hangman's sensuous daughter Esmeralda by his side.
In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.
Having quit their old gang and gone straight, Bert Allen and Joe Kemp finally own their own ranch after three years, but Joe robs the Riverton bank of the Green River Dam payroll - using Bert's horse, gun and gloves and leaving behind Bert's hat.
A group of outlaws plan and execute a robbery in a small town. However, things go awry as the team attempt a getaway, when a couple of the locals attempting to follow them, are ambushed by marauding natives.
"Nevada" and "Weary" Pierce hijack the loot taken in a bank hold-up by Les Setter, and his gang. They escape from Sheriff Jim Henry Warner. U. S. government horse-buyer David Ward is killed by Settler's men and Settler takes his papers and goes to the ranch of Blaine and asks for the horses Ward was to buy, promising payment from the government later. He also takes an interest in Ina Blaine, much to the resentment of her sweetheart Ben Ide. "Nevada" and "Weary" are hired for the horse round-up but Setter has them and Ben arrested on a fake charge.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Jim "Tex" Wall, searching for the last of the three men who raped and killed his wife, joins a gang of cattle rustlers led by Hank Hays. Both Hays' outlaws and a rival gang headed by Heesman, have been hired as ranch hands by "Bull" Herrick, a cripple who owns a large cattle ranch and wants to get his large herd to market. He theorizes that the two gangs will be kept busy watching each other and neither will rustle his cattle. Helen has little faith in her brother's contrived plan, and hates and distrusts both groups. She begins to soften toward Jim, but abruptly changes when she sees a reward poster which says he has killed two men.
Three of the original five "young guns" — Billy the Kid, Jose Chavez y Chavez, and Doc Scurlock — return in Young Guns, Part 2, which is the story of Billy the Kid and his race to safety in Old Mexico while being trailed by a group of government agents led by Pat Garrett.
After the train station clerk is assaulted and left bound and gagged, then the departing train and its passengers robbed, a posse goes in hot pursuit of the fleeing bandits.
The notorious outlaw Black Bart has reappeared and the Range Busters are sent to investigate. When they find that Black Bart is now a respectable citizen and that someone is impersonating him, they set a trap for the robber.
Bank robber Graham Dorsey spends a few hours with beautiful widow Amanda Starbuck, in which time his gang takes part in a disastrous holdup. Learning of his comrades' demise, Dorsey goes on the lam. Believing her short-term lover was killed by the law, Amanda decides to make the most of having had a liaison with the supposedly deceased desperado by writing a book about him. Much to his confusion, the still-living Dorsey watches as his name becomes legendary.
Before the U.S. Civil War rebel leader Luke Darcy sees himself as leader of a new independent Republic of Kansas but the military governor sends an ex-raider to capture Darcy.
A gunslinger returns to his hometown to warn of an impending outlaw gang attack, but he's met with hatred and fear for his previous killings.
Montana Rivers finally escapes her father who had forced her to wear men's clothing and help in robbing and cheating. She is taken in by friendly Indians and stays at their camp. Later, Akkomi, chief of the tribe, asks his friend Dan Overton to take the girl as it is not good for her to remain in the camp. Dan provides for "Tana" and falls in love with her but, because of her past, she keeps him at a distance. Jim Harris comes by and recognizes Tana as the boy robber, but when he attempts to blacken her past, Dan gives him a beating which paralyzes him. Jim then stays on with Dan, who regrets his hastiness. Eventually Tana's father appears and demands that Tana go away with him. She refuses but also does not tell Dan of this trouble.
Night riders are terrorizing homesteaders, and the town doctor tries to keep the locals from forming a vigilante group. After more towns people are killed, however, the rest of the town makes the doctor the town sheriff and tells him to clean up the gang.
Calamity Jane is a tough and rowdy woman in the old West who owns a saloon and gambling joint (and runs a cattle rustling operation as a sideline). One day she hires a pretty but naive young woman to work as a saloon girl, and finds that the girl is bringing out the maternal instincts she never knew she had. Those instincts are put to the test when a US army cavalry troop arrives to clean up the town and the girl and the young lieutenant in charge of the troop fall in love, and Calamity Jane may know something about the lieutenant that the girl doesn't.
While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.