A transgender woman takes an unexpected journey when she learns that she had a son, now a teenage runaway hustling on the streets of New York.
The brief life of Jean Michel Basquiat, a world renowned New York street artist struggling with fame, drugs and his identity.
Wyatt and Billy, two Harley-riding hippies, complete a drug deal in Southern California and decide to travel cross-country in search of spiritual truth.
Heroin addict Mark Renton stumbles through bad ideas and sobriety attempts with his unreliable friends --Sick Boy, Begbie, Spud and Tommy. He also has an underage girlfriend, Diane, along for the ride. After cleaning up and moving from Edinburgh to London, Mark finds he can't escape the life he left behind as Begbie and Sick Boy come knocking.
People in the future live in a totalitarian society. A technician named THX 1138 lives a mundane life between work and taking a controlled consumption of drugs that the government uses to make puppets out of people. As THX is without drugs for the first time he has feelings for a woman and they start a secret relationship.
The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.
Narcotics Sergeant Nick Tellis, on leave after a trauma, is called back to investigate the murder of fellow undercover operative Michael Calvess, joined by the victim's unpredictable and brutal ex-partner, Henry Oak. Working together in the back alleys of Detroit, Tellis and Oak delve into a dark investigation that leads them to uncover shocking secrets and question the corruption and morality within the department, encountering unorthodox methods and a brutal truth about Calvess's death.
When Albers takes his drug-addicted opera star sister Gerda to a sanitarium, they both become targets of slimy dope peddler Peter Lorre, who fears that Gerda will blow the whistle on him. Lorre kidnaps the woman, leading Albers on a frantic chase.
Vincent LaMarca is a dedicated and well-respected New York City police detective who has gone to great lengths to distance himself from his past, but then makes the terrible discovery that his own son has fallen into a life of crime.
Eli Johnson struggles through high school challenged by his self-loathing and the pressure to be "normal". The recent passing of his mother due to terminal cancer leaves Eli and his father disconnected and in the dark. Bullied by his peers, Eli turns to prescription drugs to cope with his suicidal thoughts. Falling hopelessly for the popular Addison McKnight, he looks to his love for her as an escape out of his deep depression.
A brilliant but impulsive young surgeon spirals into self-destruction after a painful breakup, struggling to cope with love, loss, and the consequences of his own temper.
A shy but ambitious film student falls into an intense, emotionally fraught relationship with a charismatic but untrustworthy older man.
15-year-old Beni falls in love with Fögi, a singer in a Rock band. As Fögi seduces him, he is only willing to follow him where ever Fögi wants to. But Fögi is a drug addict and pulls Beni deeper and deeper into the hell of drug addiction.
A New York press agent must scramble when his major client becomes embroiled in a huge scandal.
After her drug pusher boyfriend overdoses on heroin, a cabaret singer finds refuge from the authorities in a convent for fallen women.
While investigating a young nun's rape, a corrupt New York City police detective, with a serious drug and gambling addiction, tries to change his ways and find forgiveness.
A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.
After a friend overdoses, Spoon and Stretch decide to kick their drug habits and attempt to enroll in a government detox program. Their efforts are hampered by seemingly endless red tape, as they are shuffled from one office to another while being chased by drug dealers and the police.
Stripped of his medical license after performing an operation while high on amphetamines, famed LA surgeon Dr Eugene Sands abandons his former life only to find himself crossing paths with Raymond Blossom, an infamous counterfeiter. Employed as a "gun-shot doctor" when Raymond's associates cannot risk visiting a hospital, Eugene is lured deep into the criminal world and becomes entangled with his boss's girlfriend.
After getting into a car accident while drunk on the day of her sister's wedding, Gwen Cummings is given a choice between prison or a rehab center. She chooses rehab, but is extremely resistant to taking part in any of the treatment programs they have to offer, refusing to admit that she has an alcohol addiction.