Tim Hart (Tim McCoy), a former Texas Ranger, comes out of retirement to avenge the death of Lightnin' Ed (Frank LaRue), his foster father, who had been sent to Rainbow's End, to investigate a series of train robberies. He senses that George Johnson (Walter McGrail) and his henchman, Speck (Bob Kortman), head the robbery gang, especially after Speck makes an ambush attempt on his life.
A small-town sheriff in the American West enlists the help of a disabled man, a drunk, and a young gunfighter in his efforts to hold in jail the brother of the local bad guy.
Wealthy rancher Bick Benedict and dirt-poor cowboy Jett Rink both woo Leslie Lynnton, a beautiful young woman from Maryland who is new to Texas. She marries Benedict, but she is shocked by the racial bigotry of the White Texans against the local people of Mexican descent. Rink discovers oil on a small plot of land, and while he uses his vast, new wealth to buy all the land surrounding the Benedict ranch, the Benedict's disagreement over prejudice fuels conflict that runs across generations.
Jim Killian arrives in a small Arizona town hoping to establish a peaceful life as the local preacher, but he soon finds himself in the middle of a feud between sheep ranchers and cattlemen. Leloopa, a young Native American woman, pleads for Killian's help after her shepherd father is hung by Coke Beck, the vicious son of the head cattle rancher. Killian must weigh his actions carefully lest he perpetuate the cycle of retribution and revenge.
The brother (House Peters Jr.) of rancher Bill Martin (Bill Elliott) is killed in a stampede started by cattleman. Bill returns to the Fargo country to take his brother's place and is welcomed by law-abiding cattleman MacKenzie (Jack Ingram)) and his daughter Kathy (Phyllis Coates). The leader of the ruthless cattle interests are townsman Austin (Arthur Space) and his henchmen Red (Myron Healey), Link (Robert J. Wilke) and Albord (Terry Frost). Bill has the idea of putting up barbed wire to keep the herds from been driven over the land cultivated by the farmers. He, aided by Tad Sloan (Fuzzy Knight), produces the wire by make-shift methods, but it proves effective. The cattleman charge in court that the wire is dangerous to their herds but lose the case. Austin orders his men to seize Bill, bale him in strands of the wire, and throw him on the stage of the town hall during a fall festival. Bill doesn't take kindly to this and it precipitates open war.
Steve Kinney and his henchman, Mort, are trying to stir up trouble between the local ranchers and farmers, behind a wave of rustling and lawlessness. Mort kills Vic, a Kirby cowhand, and lays the blame on Dan Harper, the leader of the farmers faction. Storekeeper Fuzzy Q. Jones, fearful of losing the outstanding charge-accounts he has on his books, drags his reluctant pal, Billy Carson, into the fray, and the two soon prove Kinney and his henchmen to be behind the valley's troubles.
William Blake, an accountant turned fugitive, is on the run. During his travels, he meets a Native American man called Nobody, who guides him on a journey to the spiritual world.
Carl Beldon has disappeared and the Trail Blazers have been sent to investigate. Arriving in town, they find that 'Honest John' controls everything. He even prints his own money. He also has a gang and they set out to finish off the heroes.
A rancher comes home and finds that his son has been murdered and his daughter kidnapped by a bandit gang. He hires a professional tracker with a reputation for finding his quarry to help him find the gang and rescue his daughter.
A gunfighter with a reputation as a fast gun almost kills an innocent child. He makes up his mind that he is not going to carry around loaded weapons anymore, but when he's asked to become sheriff of a lawless town, he compromises by carrying an unloaded pistol and relying on his reputation to keep order.
The Durango Kid is a sort of Robin Hood of the West who helps the lovely Walters (who replaced Starrett's usual love-interest, Iris Meredith), the daughter of a homesteader, defeat the evil MacDonald who has been terrorizing the decent citizens with his gang of rustlers.
Brown fights a swindler and his pal, Hatton, finds a way to help a robbery victim buy back his property.
Banker Mason is after the ranchers land so he can resell it to the railroad for a profit. He has the railroad agent killed and replaces him with his stooge who then offers even less than Mason. But Rocky eventually suspects Mason and when Bill Anderson informs him the agent is a fake, they head out after Mason
Outlaws plan a robbery to take place during a championship prizefight in Carson City, Nevada.
Singing cowboy Whip Wilson, the foreman on a cattle drive, quits his job to pursue five bank robbers who murdered his brother.
William Munny is a retired, once-ruthless killer turned gentle widower and hog farmer. To help support his two motherless children, he accepts one last bounty-hunter mission to find the men who brutalized a prostitute. Joined by his former partner and a cocky greenhorn, he takes on a corrupt sheriff.
When attacked by two dogs, Joe Gilmore leaves them on the desert to die. Later one of the dogs saves John Blake from drowning. Men arrive claiming the dog is killing their chickens. They want to kill the dog but John convinces them the dog's fate should be determined by a trial.
An aging group of outlaws look for one last big score as the "traditional" American West is disappearing around them.
Rusty James, an absent-minded street thug, struggles to live up to his legendary older brother's reputation and longs for the days when gang warfare was going on.
In a cantina across the border, Bob Hamlin shoots a man that threatens his friend. He and his pals escape but return that night for the dance as Bob is attracted to Conchita. Running once more from the Rurales, Bob takes Conchita. They escape again only to find themselves pinned down when Buck and his gang of horse thieves attack.