Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.
After Dr. Bill Harford's wife, Alice, admits to having sexual fantasies about a man she met, Bill becomes obsessed with having a sexual encounter. He discovers an underground sexual group and attends one of their meetings -- and quickly discovers that he is in over his head.
Panic attacks and memory loss signal the plight of a writer whose body is inexplicably being taken over by another woman.
Frank Bigelow is about to die, and he knows it. The accountant has been poisoned and has only 24 hours before the lethal concoction kills him. Determined to find out who his murderer is, Frank, with the help of his assistant and girlfriend, Paula, begins to trace back over his last steps. As he frantically tries to unravel the mystery behind his own impending demise, his sleuthing leads him to a group of crooked businessmen and another murder.
Sara wakes from a coma to a life she doesn't remember; a fragile, slippery reality that spirals into a nightmare where nothing is as it seems.
When Simon awakens in the hospital after surviving a near-fatal accident, amnesia has erased the last two years from his memory. He learns that his brother was killed, he has married a woman he doesn't remember and he's haunted by strange visions of the woman he loved.
In 1947, long-retired and near the end of his life, Sherlock Holmes grapples with an unreliable memory and must rely on his housekeeper's son as he revisits the still-unsolved case that led to his retirement.
After a detective is assaulted by thugs and placed in an asylum run by Professor Baum, he observes the professor's preoccupation with another patient, the criminal genius Dr. Mabuse the hypnotist. When Mabuse's notes are found to be connected with a rash of recent crimes, Commissioner Lohmann must determine how Mabuse is communicating with the criminals, despite conflicting reports on the doctor's whereabouts, and capture him for good.
Chisako Satoya, a writer, and her father, Kozo, had a long-standing feud and had been living apart for a long time. However now that Kozo, who lives alone, has dementia, she returns to her hometown to begin taking care of him.
An Englishman has been working in the US so long he now speaks with an American accent. He is drafted into the British Army during WWII but is injured and loses his memory. Because he talks like an American, the doctors repatriate him to the States where he is housed with a New York family. After the war they all travel throughout Europe, searching for the women he still remembers in the hope of restoring his lost memory
A lonely doctor who once occupied an unusual lakeside home begins exchanging love letters with its former resident, a frustrated architect. They must try to unravel the mystery behind their extraordinary romance before it's too late.
Anne Bennett wakes up in a hospital, convinced she is recovering from minor surgery only to find herself in a battle of wits with a psychiatrist who can't let her leave until she remembers "what happened that night." Events turn a darker corner as doctor and patient try to unlock not only what traumatic event Anne is suppressing, but also who was there, why it happened, and why Anne's subconscious is fighting so hard to prevent her from talking about it.
Dan Merrick comes out from a shattering car accident with amnesia. He finds that he is married to Judith who is trying to help him start his life again. He keeps getting flashbacks about events and places that he can't remember. He meets pet shop owner and part time private detective Gus Klein who has supposedly done some work for him prior to the accident. Klein helps Merrick to find out more...
Newly divorced lawyer Nathan Del Amico is shaken up after he meets a doctor who claims that he can sense when select people are about to die. Though he doesn't believe the doctor, events in Nathan's life slowly make him think he's not long for this world.
A brilliant researcher spirals through time, grappling with chaotic shifts that lead him to a dystopian future. Guided by a cryptic elder, he confronts the dire consequences of his actions, racing to alter his fate before it’s too late.
After a car crash, criminal psychologist Dr. Miranda Grey regains consciousness only to find that she's a patient in the same mental institution that currently employs her. She's been accused of murdering her husband Dr. Douglas Grey — but she has no memory of committing the crime. As she tries to regain her memory and convince her co-worker, Dr. Pete Graham, of her innocence, a vengeful spirit uses her as an earthly pawn, which further convinces everyone of her guilt.
Washington, D.C. psychologist Carol Bennell and her colleague Dr. Ben Driscoll are the only two people on Earth who are aware of an epidemic running rampant through the city. They discover an alien virus aboard a crashed space shuttle that transforms anyone who comes into contact with it into unfeeling drones while they sleep. Carol realizes her son holds the key to stopping the spread of the plague and she races to find him before it is too late.
Ten strangers are summoned to a remote island and while they are waiting for the mysterious host to appear, a recording levels serious accusations at each of the guests. Soon they start being murdered, one by one. As the survivors try to keep their wits, they reach a disturbing conclusion: one of them must be the killer.
Forensic psychologist and detective Alex Cross travels to North Carolina and teams with escaped kidnap victim Kate McTiernan to hunt down "Casanova," a serial killer who abducts strong-willed women and forces them to submit to his demands. The trail leads to Los Angeles, where the duo discovers that the psychopath may not be working alone.
The wife of an American doctor suddenly vanishes in Paris. To find her, he navigates a puzzling web of language, locale, laissez-faire cops, triplicate-form filling bureaucrats and a defiant, mysterious waif who knows more than she tells.