Eccentric consulting detective Sherlock Holmes and Doctor John Watson battle to bring down a new nemesis and unravel a deadly plot that could destroy England.
Mary Gray elopes to Atlantic City, NJ, but begins having second thoughts about the marriage. Then she becomes inexplicably locked in her hotel room, and a series of cops, robbers and kidnappers passes through. Desperate, Mary trusts the shifty chambermaid Clara who whisks her away to the mansion of wealthy George Blaine. There, Mary must pretend to be a lowly cook, but that seems better than sticking with the guy she was engaged to.
Sherlock Holmes and Dr. Watson meet as boys in an English Boarding school. Holmes is known for his deductive ability even as a youth, amazing his classmates with his abilities. When they discover a plot to murder a series of British business men by an Egyptian cult, they move to stop it.
The corpse of a shabbily dressed young woman has been discovered in the mud flats of the Thames at low tide. Police assume she's a prostitute, but Dr. Watson suspects something more and goes to his old friend Holmes, now retired and at very loose ends.
An ancient Egyptian priest named Imhotep is revived when an archaeological expedition finds his mummy and one of the archaeologists accidentally reads an ancient life-giving spell. Imhotep escapes from the field site and searches for the reincarnation of the soul of his lover.
Chick Hewes is released from prison and finds work as an accountant. Two years later, Chick's crooked friend, Benny LaMarr, to whom he is indebted for past kindnesses, steals a diamond necklace from the home safe of the district attorney. When the district attorney threatens to accuse the police of inefficiency in crime fighting, Garvey, who is campaigning for the office of police commissioner, promises to catch the thief in twenty-four hours.
Holmes and Dr. Watson take on the case of a beautiful woman whose husband has vanished. The investigation proves strange indeed, involving six missing midgets, villainous monks, a Scottish castle, the Loch Ness monster, and covert naval experiments.
When Captain Howland decides that his daughter Tess is getting a bit to old to continue to go to sea with him, they move into a small cottage on the coast of Maine, but not for long. A local millionaire, Frederick Garfield, lays a false claim to the property and has them evicted. Later, when Tess saves a young man about her age from drowning, she is a bit dismayed to learn that he is Garfield's son. But when her father is jailed on a false-accusation charge of murder, the younger Garfield comes to their aid and proves he himself.
An expedition enters an area of the Congo jungle to investigate reports of a gorilla-worshipping tribe.
Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".
When legendary hunter Bob Rainsford is shipwrecked on the perilous reefs surrounding a mysterious island, he finds himself the guest of the reclusive and eccentric Count Zaroff. While he is very gracious at first, Zaroff eventually forces Rainsford and two other shipwreck survivors, brother and sister Eve and Martin Towbridge, to participate in a sadistic game of cat and mouse in which they are the prey and he is the hunter.
Two dubious characters disguise themselves as Holmes and Watson to gain attention and end up chasing counterfeiters and stolen stamps.
A husband and wife detective team takes on the search for a missing inventor and almost get killed for their efforts.
Dr. Henry Jekyll believes that there are two distinct sides to men - a good and an evil side. He believes that by separating the two, man can become liberated. He succeeds in his experiments with chemicals to accomplish this and transforms into Hyde to commit horrendous crimes. When he discontinues use of the drug, it is already too late.
An obsessed scientist conducts profane experiments in evolution, eventually establishing himself as the self-styled demigod to a race of mutated, half-human abominations.
Tampering with life and death, Henry Frankenstein pieces together salvaged body parts to bring a human monster to life; the mad scientist's dreams are shattered by his creation's violent rage as the monster awakens to a world in which he is unwelcome.
A Depression-downtrodden waif uses her brains instead of her body to rise from tyro con artist to crime boss.
A salesman gets in trouble with a party girl and a debutante in Detroit.
A wisecracking New York reporter intrudes on a research scientist's quest to unmask The Moon Killer.
Gabby Denton, a hard-drinking, down-on-his-luck drifter, seems to get a chance at redemption when his brother-in-law helps get him a job as a mechanic. Not realizing the garage he works for is actually a front for a stolen car ring, Gabby soon finds himself mixed up in both murder and a liaison with the boss's girl.