Sherlock Holmes and Dr. Watson embark on a search for Cleopatra's ancient necklace, which has been stolen.
When Watson reads from the newspaper there have been two similar murders near Whitechapel in a few days, Sherlock Holmes' sharp deductive is immediately stimulated to start its merciless method of elimination after observation of every apparently meaningless detail. He guesses right the victims must be street whores, and doesn't need long to work his way trough a pawn shop, an aristocratic family's stately home, a hospital and of course the potential suspects and (even unknowing) witnesses who are the cast of the gradually unraveled story of the murderer and his motive.
For years, a blackmailer has been preying on the weaknesses of others throughout London. When Holmes hears of the utter misery this mystery man is creating, he adopts a campaign to thwart his evil scheming. The campaign astonishes Dr. Watson by its strangeness and finds Holmes falling in love.
Having once again avoided criminal conviction, Professor Moriarity develops a murderous plan to “finish off” his last major nemesis, Sherlock Holmes, by making him fail to prevent the perfect crime. Does it involve a family curse, the crown jewels of England, or something else…
In the midst of World War II, Sherlock Holmes rescues the Swiss inventor of a new bomb-sight from the Gestapo and brings him to England, where he quickly falls into the clutches of the evil Professor Moriarty.
Sherlock Holmes investigates when young women around London turn up murdered, each with a finger severed. Scotland Yard suspects a madman, but Holmes believes the killings to be part of a diabolical plot.
Sherlock Holmes is drawn into the case of Jack the Ripper, who is killing prostitutes in London's East End. Assisted by Dr. Watson, and using information provided by a renowned psychic, Robert Lees, Holmes finds that the murders may have their roots in a Royal indiscretion and that a cover-up is being managed by politicians at the highest level, all of whom happen to be Masons.
There is a new criminal mastermind at large (Professor Moriarty) and not only is he Holmes’ intellectual equal, but his capacity for evil and lack of conscience may give him an advantage over the detective.
Sir Arthur Conan Doyle's Sherlock Holmes - the world's greatest detective - faces a most alluring adversary... Legendary opera star Irene Adler is threatening to destroy the King of Bohemia's reputation with proof of their illicit affair. The evidence? A photograph. Her ransom? The king's hand in marriage. But not only does investigating detective Sherlock Holmes already know Irene from the past, he also knows that the queen of manipulation would never resort to such a common crime. After uncovering her true ambitions, Holmes draws the cunning songstress into a well-matched game of cat and mouse
Sherlock Holmes investigates strange and tragic happenings in a village that appear linked to a man who seems to be like a vampire.
During WWII several murders occur at a convalescent home where Dr. Watson has volunteered his services. He summons Holmes for help and the master detective proceeds to solve the crime from a long list of suspects including the owners of the home, the staff and the patients recovering there.
After the King of Rovenia has been assassinated, Holmes and Watson are engaged to escort his son to Europe via Algiers, aboard a transatlantic ocean liner which also carries a number of suspicious persons, any of whom may be involved in a plot to also assassinate him.
Holmes, retired to Sussex, is drawn into a last case when his arch enemy Moriarty arranges with an American gang to kill one John Douglas, a country gentleman with a mysterious past. Holmes' methods baffle Watson and Lestrade, but his results astonish them. In a long flashback, the victim's wife tells the story of the sinister Vermissa Valley.
After her sister dies under mysterious circumstances, a young heiress seeks Holmes' help when she feels threatened by her brutish stepfather.
Early in his crime-solving career, Sherlock Holmes attempts to prevent Moriarty from cornering the heroin market.
Holmes takes a vacation and visits his old friend Sir Henry Baskerville. His vacation ends when he suddenly finds himself in the middle of a double-murder mystery. Now he's got to find Professor Moriarty and the horse Silver Blaze before the great cup final horse race.
In World War II, a British secret agent carrying a vitally important document is kidnapped en route to Washington. The British government calls on Sherlock Holmes to recover it.
In a mansion full of secret rooms and passageways, people are dying shortly after seeing the ghost of a woman in gray, as an old legend dictates. Called in to solve the mystery, Sherlock Holmes has doubts about the supernatural aspect of the crimes and focuses on a more earthly culprit.
Rio de Janeiro, 1886. A precious Stradivarius violin presented to Emperor Dom Pedro II is stolen. Sherlock Holmes and Dr. Watson are called to solve the case.
In London, a secret society led by lawyer Thaddeus Merrydew collects the assets of any of its deceased members and divides them among the remaining members. Society members start dropping like flies. Sherlock Holmes is approached by member James Murphy's widow, who is miffed at being left penniless by her husband. When Captain Pyke is shot, Holmes keys in on his mysterious Chinese widow as well as the shady Merrydew. Other members keep dying: Malcom Dearing first, then Mr. Baker. There is also an attempt on the life of young Eileen Forrester, who became a reluctant society member upon the death of her father. Holmes' uncanny observations and insights are put to the test.