A Spanish cat is more interested in playing flamenco guitar than trying to catch the mouse El Magnifico (Jerry). Tom arrives from the States with world champion mouse-catching credentials to have a go.
Tom chases Jerry through the streets of Naples; they meet a local mouse who recognizes them from their cartoons and shows them around. Meanwhile, some local dogs are shadowing them.
Tom settles in for a day at the beach with his sweety, accidentally ruining Jerry's day. Meanwhile, Tom's girl is paying more attention to the bodybuilders than to Tom.
Tom has amnesia and believes he's a mouse. Jerry, finding him more obnoxious as a fellow rodent than as a cat, seeks to cure him with a blow to the head.
The Bide A Wee Mouse Home has sent the orphan mouse Nibbles to spend Thanksgiving with Jerry. Unfortunately, Nibbles is always hungry.
Tom steals an egg from a mother duck's nest, but soon the resultant hatchling runs away from the cat and into a mouse hole, where it finds an able protector in Jerry.
Tom reads Jerry's best selling book, "Life with Tom" and experiences some flashbacks.
Tom pretends to have a cold in order to trick Mammy into letting him stay inside for the night. Jerry tricks Tom by making him think he really is sick - with the measles.
Jerry's eccentric uncle, Pecos, a Texan mouse, comes to spend the night with him before his musical performance on television the next day. He decides to rehearse with his guitar for the performance but each time he plays, one of his guitar strings snaps off. Fortunately, he is able to replace them by plucking off one of Tom's whiskers each time. Tom is rather reluctant about this and tries to hide to protect his whiskers from Uncle Pecos.
The couple that owns Tom and Spike decides they can't afford to keep both. They agree that the first one to catch the mouse can stay - bad news for Jerry.
Tom, complete with mortarboard, is teaching a kitten the basics: "cats chase mice." But Jerry keeps subverting this lesson at every opportunity.
Spike is taking his son on a picnic. Jerry keeps hiding in the basket, so Tom keeps disrupting the picnic while chasing him.
Jerry rescues a bag of puppies from the river. Most of them run away as soon as Jerry releases them, but one stays behind. Jerry tries to get rid of it, but ultimately takes pity and invites the frisky pup inside, where he has to hide it from Tom, who keeps throwing it out.
Tom's being especially lazy, which makes it even easier for Mammy to toss him out when her new mouse-catching robot cat, Mechano, arrives. Mechano is frighteningly efficient, foiling several attempts by Jerry. Jerry turns this efficiency against him by unleashing several mechanical mice; the zealous robot makes a shambles of the house, and finally itself, in the process of chasing them down. Tom is welcomed back, but at the last moment, a key part of the robot had gone down Tom's throat; Jerry activates it, and sends Tom chasing after one of the wind-up mice.
Tom and Jerry are in a cabin in the wild west. Jerry's rustling food, so Tom's owner won't let him eat until he's gotten rid of Jerry.
A baby seal escapes from the circus and ends up in Jerry's backyard pool. Tom finds out soon enough, and when the circus offers a $10,000 reward, his goal is clear.
Professor Jerry teaches a course in how to outwit cats, but his pupil seems to know more than Jerry.
Spike is showing his son Tyke how to barbecue when his cooking is disrupted by a typical Tom-and-Jerry chase.
After Tom's mistress orders him to clean up the mess he made while chasing Jerry, Tom spies an ad for a cat needed as companion to an old lady. Tom leaves his current home for what he anticipates will be a better life, only to discover the old lady is a witch.
Tom filches a drumstick from a fresh-baked chicken. When Mammy is about to discover him, he hands it off to Jerry; this lets him be a hero to Mammy and still get his chicken. Jerry is miffed, and sees his chance to retaliate: Spike is very possessive of his bone. Jerry keeps stealing the bone and planting it on Tom. Finally, Jerry bores a hole in the bone, inserts a bolt, and gets Tom to swallow a magnet. The bone keeps coming back to Tom, even through a fence. Finally, as Tom runs off followed by Spike, Jerry, who's been hiding in a tin can, is also dragged along.