Three of the original five "young guns" — Billy the Kid, Jose Chavez y Chavez, and Doc Scurlock — return in Young Guns, Part 2, which is the story of Billy the Kid and his race to safety in Old Mexico while being trailed by a group of government agents led by Pat Garrett.
Isaac LeMay, a murderous outlaw, learns he is cursed by a prophecy: one of his children will kill him. To prevent this, he hunts down each of his estranged children, including long-lost son Cal. With bounty hunters and Sheriff Solomon on his tail, LeMay must find a way to stop his children and end the curse.
Bank robber Graham Dorsey spends a few hours with beautiful widow Amanda Starbuck, in which time his gang takes part in a disastrous holdup. Learning of his comrades' demise, Dorsey goes on the lam. Believing her short-term lover was killed by the law, Amanda decides to make the most of having had a liaison with the supposedly deceased desperado by writing a book about him. Much to his confusion, the still-living Dorsey watches as his name becomes legendary.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
Night riders are terrorizing homesteaders, and the town doctor tries to keep the locals from forming a vigilante group. After more towns people are killed, however, the rest of the town makes the doctor the town sheriff and tells him to clean up the gang.
Montana Rivers finally escapes her father who had forced her to wear men's clothing and help in robbing and cheating. She is taken in by friendly Indians and stays at their camp. Later, Akkomi, chief of the tribe, asks his friend Dan Overton to take the girl as it is not good for her to remain in the camp. Dan provides for "Tana" and falls in love with her but, because of her past, she keeps him at a distance. Jim Harris comes by and recognizes Tana as the boy robber, but when he attempts to blacken her past, Dan gives him a beating which paralyzes him. Jim then stays on with Dan, who regrets his hastiness. Eventually Tana's father appears and demands that Tana go away with him. She refuses but also does not tell Dan of this trouble.
Before the U.S. Civil War rebel leader Luke Darcy sees himself as leader of a new independent Republic of Kansas but the military governor sends an ex-raider to capture Darcy.
Calamity Jane is a tough and rowdy woman in the old West who owns a saloon and gambling joint (and runs a cattle rustling operation as a sideline). One day she hires a pretty but naive young woman to work as a saloon girl, and finds that the girl is bringing out the maternal instincts she never knew she had. Those instincts are put to the test when a US army cavalry troop arrives to clean up the town and the girl and the young lieutenant in charge of the troop fall in love, and Calamity Jane may know something about the lieutenant that the girl doesn't.
Narrowly escaping death, outlaw Johnny Madrid goes on the run with the hangman's sensuous daughter Esmeralda by his side.
Questions arise when Senator Stoddard (James Stewart) attends the funeral of a local man named Tom Doniphon (John Wayne) in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance (Lee Marvin). As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
Residents of a small frontier town take up arms when vigilantes try to block a railroad right-of-way.
Expert conman Joe Thanks teams up with half-breed Bill and naive Lucy to steal $300,000 from the Indian-hating Major Cabot. Their elaborate plan is full of disguises, double-crosses, and chases, but Joe always seems to know what he's doing.
U.S Marshal Mike Donovan has dark memories of the death of his first love. He keeps peace between the Americans and the natives who had temporarily adopted and taken care of him. The evil actions of a white sorcerer lead him to confront the villain in the Sacred Mountains, and, through shamanic rituals conquer his fears and uncover a suppressed memory he would much rather deny.
A gunfighting stranger comes to the small settlement of Lago. After gunning down three gunmen who tried to kill him, the townsfolk decide to hire the Stranger to hold off three outlaws who are on their way.
A group of young gunmen, led by Billy the Kid, become deputies to avenge the murder of the rancher who became their benefactor. But when Billy takes their authority too far, they become the hunted.
The epic tale of the development of the American West from the 1830s through the Civil War to the end of the century, as seen through the eyes of one pioneer family.
Outlaws plan a robbery to take place during a championship prizefight in Carson City, Nevada.
After the train station clerk is assaulted and left bound and gagged, then the departing train and its passengers robbed, a posse goes in hot pursuit of the fleeing bandits.
The notorious outlaw Black Bart has reappeared and the Range Busters are sent to investigate. When they find that Black Bart is now a respectable citizen and that someone is impersonating him, they set a trap for the robber.
Two championship rodeo partners travel to New York to find their missing friend, Nacho Salazar who went missing there.