One of Hoppy's Bar 20 ranch hands is tricked into participating in nefarious activities after being subjected to hypnosis.
Hoppy is leading a scientific expedition and the Chinese who have a hidden settlement nearby are trying to stop them. Saulters and his outlaw gang are also in the area looking for a gold mine. When Saulters men attack, the gold mine is found. Hoppy agrees to file for the Chinese and heads after Saulters in the chase to the land office.
Hoppy, California, and Lucky travel to Mesa City for a short vacation. California buys new clothes and carrying his old ones in a suitcase, bumps into escaping bank robbers in the dark. His suitcase gets switched with that of the robbers and he is seen with the money. Hoppy must find the money that has mysteriously disappeared and also the robbers so that he can clear California who is now in jail.
A young Eastern lawyer, seriously injured in a stage holdup, secures the help of Hoppy, California and Jimmy in completing his mission to his woman cousin's ranch in Texas. The ranch, as are others in the same area, is being plagued by a gang called the Night Riders, while the friendly local town lawyer is trying to cajole the cousin into selling out to him. Hoppy begins by arriving in the town, separate from his pals, all spiffed up and dandified, posing as the Eastern lawyer...
Hoppy, California and Lucky take refuge from a storm inside a supposedly abandoned church outside a ghost town, only to meet a young woman and her mother there, then find themselves surrounded by a gang of "workmen" intent on tearing down the church if they have to kill the five to do it.
Hoppy and his pals arrive in a remote town to investigate the counterfeiting of both U.S. and Mexican money; his only clues are the name "Mordigan" and a drawing of a comet. He quickly finds out that Mordigan is the town "boss"; but what or who is "the comet", and why are Mordigan and his henchmen intent on persecuting a young woman, her drunken brother, and her deathly ill sister-in-law who've also just arrived in town?
Hoppy, California and Johnny come to the ranch of a friend and his daughter, disguised as dude detectives from the east, to investigate the disappearances, without a trace, of several herds of cattle.
Hoppy, Johnny and California go to Arabia to buy some horses. There they get involved with a sheik and a harem and a kidnapping plot.
Burton is after Clark's ranch. He gets the banker to refuse to renew Clark's note and then sends his men to rustle his cattle. Hoppy is Clark's new foreman and is on to Burton's scheme. But just as he learns of the rustling and is about to go after the gang, the Sheriff arrives and arrests him for hiding Johnny who has been accused of robbery.
Stagecoach robbers take the money Hoppy was going to use to buy cattle so Hoppy, California and Lin go after them.
When the outlaw El Toro saves Hoppy's life, Hoppy agrees to find his missing grandson.
Hoppy's friend Dennis owns a rich gold mine. Frazier who owns the adjoining mine and wants the Dennis mine, has Dennis killed. Hoppy steps in to take over running the Dennis mine and learns Frazier's men sneak into and work the Dennis mine at night. Hoppy captures one of Frazier's men only to be captured in return by Frazier and left to die in a burning building.
The local school is causing Hoppy problems. First Bar 20 cattle are stolen when Hoppy investigates a problem there. Then the new teacher arrives and disrupts the routine of the Bar 20 hands. Later with the Bar 20 hands at graduation, the rustlers are poised to strike again. But there is dissension among them and this will lead to the break that Hoppy needs.
Caldwell and Nixon have their men rob the stage and then critcize the Sheriff for not catching the robbers. With her father the Sheriff under pressure, Mary sends for Hoppy who finds the stolen money and sets a trap to bring in the entire gang.
When three Texas Rangers try to investigate kidnapped Mexicans being used as forced labor in the mines of Silver Bullet, they are framed for murder by the town's corrupt sheriff.
Stephen Westcott and Ed Martin scheme to put Jane Travers' wagon line out of business. They want to use it take over all the wagon- train traffic going west. Hoppy, California and Lucky must make sure that doesn't happen.
Hoppy goes undercover as a gambler from the East when Bar 20 cattle are stolen by unknown rustlers. Brennan/Talbot are twin brothers (one a casino owner, the other a rancher) and Hoppy believes they provide alibis for each other while one is out committing crimes. Hoppy gets a job in the casino to learn more but is exposed when a gambling gunslinger notices him.
U.S. Marshal Hopalong Cassidy is called when a town becomes overun with bad guys. Disguised as a member of a medicine show, Hoppy discovers that the ringleader is none other than sweet li'l ol' Ma Burton.
An evil gang is involved in both cattle rustling and the robbing of stagecoaches. Hoppy must stop them without help from the sheriff who turns out be a major outlaw himself.
A crusading newspaper editor recruits his old friend Hoppy to take the job of Marshall in a town rife with vice and murder directed at helpless miners.