Vignettes weaving together the stories of six individuals in the old West at the end of the Civil War. Following the tales of a sharp-shooting songster, a wannabe bank robber, two weary traveling performers, a lone gold prospector, a woman traveling the West to an uncertain future, and a motley crew of strangers undertaking a carriage ride.
The Louisiana Purchase is imminent and Gilmore is smuggling guns into St. Louis so his men can make him Governor of the new Louisiana Territory. But John Colfax fights to defeat Gilmore.
Fuzzy's niece is killed in a stagecoach hold-up. Billy and Fuzzy quickly learn that the culprit, who not only killed all the passengers but also absconded with $40,000, may be holed up in lawless Pecos City.
Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.
James Kincaid controls the local water supply and plans to do away with the other ranchers. Government agent Sandy Saunders arrives undercover to investigate Kincaid's land swindle scheme, and win the heart of one of his victims, Fay Denton.
Ellen has the contract for the South West Stage Line through the panhandle. Her father had the run for years and Haney, who runs the office, worked for him. But Ellen does not know that Haney is in league with Elkins and they want the stage line so they can rob the gold shipments. All they need do is stop the stage and end her contract, but that is not easy with Dave driving for Ellen.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
Gallant Cisco "kidnaps" murder suspect Ellen from the authorities, then sets about to prove her innocence, all with the cooperation of a sympathetic sheriff.
A young woman arrives in the western town of Headstone and helps the locals outsmart a gang of outlaws.
Jesse W. Haywood (Don Knotts) graduates from dental school in Philadelphia in 1870 and goes west to become a frontier dentist. Penelope "Bad Penny" Cushing (Barbara Rhoades) is offered a pardon if she will track down a ring of gun smugglers. She tricks Haywood into a sham marriage as a disguise. Haywood inadvertently becomes the legendary "Doc the Haywood" after he guns down "Arnold the Kid".
Crooked ranch foreman Thatcher sends his two henchmen, Parnell and Clint, out to murder his boss, wealthy Peter Arnold who has just arrived to retire on his ranch, bringing in tow his daughter, tomboy Jessie, who despises western life and can't wait to run off back to San Francisco. Stagecoach line owner Dave Collins and his sidekick Chito show up just in time to deter the attackers. Collins isn't done yet, though, as a gold shipment sent on one of his stages is stolen by Parnell and Clint, one of whom is recognized by Jessie, attempting to escape back to the west coast. Collins has his hands full trying to retrieve the stolen gold, and dealing with Jessie, who's fallen head-over-heels in love with him.
Union officer Kerry Bradford escapes from a Confederate prison and races to intercept $5 million in gold destined for Confederate coffers. A Confederate sympathizer and a Mexican bandit, each with their own stake in the loot, stand in his way.
The romance of a rancher's niece and a rival rancher's son parallels that of a stallion and a mare.
The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.
When Rocklin arrives in a western town he finds that the rancher who hired him as a foreman has been murdered. He is out to solve the murder and thwart the scheming to take the ranch from its rightful owner.
Raton Pass is a curious western based on the rules of Community Property. Dennis Morgan and Patricia Neal portray a recently married husband and wife, each of whom owns half of a huge cattle ranch. Neal is a tad more ambitious than her husband, and with the help of a little legal chicanery she tries to obtain Morgan's half of the spread. He balks, so she hires a few gunslingers to press the issue. In a 1951 western, the greedy party usually came to a sorry end; Raton Pass adheres strictly to tradition.
Stodge City is in the grip of the Rumpo Kid and his gang. Mistaken identity again takes a hand as a 'sanitary engineer' named Marshal P. Knutt is mistaken for a law marshal. Being the conscientious sort, Marshal tries to help the town get rid of Rumpo, and a showdown is inevitable. Marshal has two aids—revenge-seeking Annie Oakley and his sanitary expertise.
A jobless cowpuncher rides into Cottonwood, Arizona in search of the man who swindled his father.
When a fed-up businessman tires of watching gold shipments disappear without a trace, he calls in the Trail Blazers (Ken Maynard, Hoot Gibson and Bob Steele) -- a legendary trio of law enforcers -- to find the gold and figure out who's behind the thefts.