The TARDIS materialises in Paris in the year 1572 and the Doctor decides to visit the famous apothecary Charles Preslin. Steven, meanwhile, is befriended by a group of Huguenots from the household of the Protestant Admiral de Coligny. Having rescued a young serving girl, Anne Chaplet, from some pursuing guards, the Huguenots gain their first inkling of a heinous plan being hatched at the command of the Catholic Queen Mother, Catherine de Medici.
The Doctor and his companions Steven Taylor and Dodo Chaplet arrive some ten million years into the future, on board a generation starship which is carrying the last of humanity away from an Earth that is about to fall into the Sun. However, the cold that Dodo has could prove devastating to these future humans and their servants, the Monoids.
The travellers arrive in a strange domain presided over by the Celestial Toymaker — an enigmatic, immortal entity who forces them to play a series of games, failure at which will render them his playthings for all eternity.
The TARDIS has arrived on a far-distant and seemingly idyllic world. Yet the Doctor, Steven and Dodo learn it hides a terrible secret: the apparently civilised Elders maintain their advanced society by draining and transferring to themselves the life-force of the defenceless Savages.
The TARDIS arrives in London in 1966 and the First Doctor and Dodo visit the Post Office Tower. There they meet Professor Brett, whose revolutionary new computer WOTAN (Will Operating Thought ANalogue) can actually think for itself and is shortly to be linked up to other major computers around the world — a project overseen by civil servant Sir Charles Summer.
The time travellers arrive in Scotland just after the Battle of Culloden. The Second Doctor gains the trust of a small band of fleeing Jacobites by offering to tend to their wounded Laird, Colin McLaren. While Polly and the Laird's daughter, Kirsty, are away fetching water, he and the others are all captured by Redcoat troops commanded by Lieutenant Algernon Ffinch.
The TARDIS arrives on an extinct volcanic island. Before long, the travellers are captured and taken into the depths of the Earth, where they find a hidden civilisation — the lost city of Atlantis.
Time itself is in peril! The Time Lords and UNIT find themselves besieged by a mythic figure from the Time Lords' past hell-bent on destruction. The only way to defeat him is to break the First Law of Time and let the Doctor help himself — literally...
A young woman from the future forces a local gunman to help her stop an impending alien invasion which will wipe out the human race.
Fourteen-year-old Henry and his friends are about to change history. Sneaking into the apartment of an eccentric Clockmaker, the kids discover that the old man controls time for the entire world through an incredible array of magnificent timepieces and weird machines. When one of the curious kids accidentally pushes a wrong button and gets launched back in time, the space-time continuum is severely disrupted. As everything begins to change around them, the young adventurers must travel back in time to save their friend...and the future
High school student Aoi Aioi lives with her elder sister, Akane, after a tragic accident took their parents away 13 years ago. Because Akane has since been taking care of her single-handedly, Aoi wants to move to Tokyo after her graduation to relieve her sister's burden and pursue a musical career, inspired by Akane's ex-boyfriend Shinnosuke "Shinno" Kanamuro. Shinno was part of a band until he left for Tokyo to become a professional guitarist after the sisters' parents passed away, and he was never to be seen again.
On the planet Alzarius in the alternate universe of E-Space, the Doctor, Romana and K9 find survivors of a crashed starliner, strange creatures lurking in the marshes and a genetic riddle which stretches back centuries.
Still trapped in E-Space, the Doctor, Romana, Adric and K9 encounter a medieval civilisation dominated by the Three Who Rule, vampires who govern from their mighty castle.
The Doctor, Romana, Adric and K9 encounter the enslaved time-sensitive Tharils, who lead them to a white void occupied only by the ruins of an old building and a spaceship - a dimension that might be the key to escaping E-Space.
Picking up a distress call from the edge of the known universe, the Doctor and Sarah Jane find themselves on Zeta Minor where a geological team has run afoul of some strange goings on...
The TARDIS arrives in 2070 on the Moon, where a weather control station under the command of a man named Hobson is in the grip of a plague epidemic — in reality the result of an alien poison planted by the Cybermen. Jamie is knocked unconscious and lapses into a delirium, leaving the Second Doctor, Ben, and Polly to fight off a massive Cyberman attack.
The Doctor and his companions must prevent the Cybermen from bombing the Earth in the 26th century. It is a battle not everyone will survive...
The Doctor, Jamie and Zoe arrive on an unnamed planet. At first believing themselves in the midst of World War I, they realise it to be one of many War Zones overseen by the War Lords, who have kidnapped large numbers of human soldiers to form the greatest army the universe has ever seen. At the helm of this plot is the War Chief, another renegade Time Lord like the Doctor. The creeping realisation sets in that the Doctor cannot solve this problem alone, and that his days of wandering may be at an end...
Professor Emil Keller has created a machine that can pacify even the most dangerous of criminals. But when the Doctor and Jo arrive at Stangmoor Prison for a demonstration, things start to go horribly wrong - especially when they discover that the Doctor's old enemy the Master is responsible for the machine.
The Second Doctor and Jamie arrive on what appears to be a space station called the "Wheel in Space" it's here that they meet Zoe Herriot a young parapsychology librarian, The Doctor hits his head concussing him leaving Jamie and Zoe to defend off the Cybermen from taking over "The Wheel in Space."