Lincoln Rhyme was the department's top homicide detective and leading expert in criminal forensics until an injury left him paralyzed, depressed, and incapable of working. But when a gruesome murder in Manhattan leaves detectives baffled, they call on Rhyme to help solve the mystery. Amelia Donaghy, a rookie cop whose quick thinking preserved a gruesome murder scene, is enlisted by Rhyme to be his on-the-scene forensics expert. With Amelia reluctantly acting as Rhyme's able-bodied go-between, the pair piece together cryptic clues the killer leaves behind at the scene of the crime, hoping to catch the grisly serial killer.
Still recovering from a heart transplant, a retired FBI profiler returns to service when his own blood analysis offers clues to the identity of a serial killer.
A former government operative renowned for his stealth, Jack Cole is now a Los Angeles police detective. When a series of horrible murders occurs in the metro area, Cole is assigned to the case, along with tough-talking fellow cop Jim Campbell. Although the two men clash, they gradually become effective partners as they uncover a conspiracy linked to the killings, which also involves terrorism and organized crime.
Three converging story lines involving bootleggers, a serial killer and drug dealers are followed. A former drug dealer tries to go straight, but comes across a stash of stolen drugs. Meanwhile, a middle-aged suburban housewife hides a sadistic and vicious streak.
Former FBI Agent Will Graham, who was once almost killed by the savage Hannibal 'The Cannibal' Lecter, now has no choice but to face him again, as it seems Lecter is the only one who can help Graham track down a new serial killer.
On a stormy night, young Jim, who transports a luxury car from Chicago to California to deliver it to its owner, feeling tired and sleepy, picks up a mysterious hitchhiker, who has appeared out of nowhere, thinking that a good conversation will help him not to fall asleep. He will have enough time to deeply regret such an unmeditated decision.
Raised as a slave, Danny is used to fighting for his survival. In fact, his "master," Bart, thinks of him as a pet and goes as far as leashing him with a collar so they can make money in fight clubs, where Danny is the main contender. When Bart's crew is in a car accident, Danny escapes and meets a blind, kindhearted piano tuner who takes him in and uses music to free the fighter's long-buried heart.
After having successfully eluded the authorities for years, Hannibal peacefully lives in Italy in disguise as an art scholar. Trouble strikes again when he's discovered leaving a deserving few dead in the process. He returns to America to make contact with now disgraced Agent Clarice Starling, who is suffering the wrath of a malicious FBI rival as well as the media.
Major crimes unit detective Seong-jin arrests Tae-sung for petty crimes, but shocked to find out that he is the notorious serial killer. However, Seong-jin becomes doubtful of his identity as the serial murder case is investigated.
Marshall Lawson is the commander of an elite military unit. Marshall Lawson loses his strike-team in a cold-blooded and seemingly random attack, and he takes it upon himself to investigate the attack, with the help of his girlfriend Tia and his friend Dwayne.
The activities of rampaging, indiscriminate serial killer Ben are recorded by a willingly complicit documentary team, who eventually become his accomplices and active participants. Ben provides casual commentary on the nature of his work and arbitrary musings on topics of interest to him, such as music or the conditions of low-income housing, and even goes so far as to introduce the documentary crew to his family. But their reckless indulgences soon get the better of them.
A man is questioned on the "Claude killings" in Los Angeles.
A killer dressed in a police uniform begins murdering innocent people on the streets of New York City.
The sought-after images of top model Jennifer adorn magazine covers and billboards worldwide. When alone at a club, she is abducted and incarcerated in a cell with another prisoner. When their captor subjects the two to torture, they commit to escaping the chamber of horrors before they're killed.
A troubled and violent detective investigates a series of serial killer murders in Memphis, Tennessee.
In 1978, Rodney Alcala won a date on the popular TV show, The Dating Game. What no one knew was that he was a prolific serial killer in the middle of a cross-country murder spree.
A mysterious man arrives at the offices of an FBI agent and recounts his childhood: how his religious fanatic father received visions telling him to kill people who were in fact "demons."
Seen-it-all New York detective Frank Keller is unsettled - he has done twenty years on the force and could retire, and he hasn't come to terms with his wife leaving him for a colleague. Joining up with an officer from another part of town to investigate a series of murders linked by the lonely hearts columns he finds he is getting seriously and possibly dangerously involved with Helen, one of the main suspects.
A death-obsessed cleaning woman uncovers a clue identifying a Florida bartender for a series of socialite murders.
Following Jigsaw's grisly demise, Detective Mark Hoffman is commended as a hero, but Agent Strahm is suspicious, and delves into Hoffman's past. Meanwhile, another group of people are put through a series of gruesome tests.