Elizabeth has just been through a particularly nasty breakup, and now she's ready to leave her friends and memories behind as she chases her dreams across the country. In order to support herself on her journey, Elizabeth picks up a series of waitress jobs along the way. As Elizabeth crosses paths with a series of lost souls whose yearnings are even greater than her own, their emotional turmoil ultimately helps her gain a greater understanding of her own problems...
Rhode Island State Trooper Charlie Baileygates has a multiple personality disorder. One personality is crazy and aggressive, while the other is more friendly and laid back. Both of these personalities fall in love with the same woman named Irene after Charlie loses his medication.
On their cross-country drive, a married couple, Jeff and Amy Taylor, experience car trouble after their SUV breaks down. Stranded in the New Mexico desert, the two catch a break when a passing truck driver offers Amy a ride to a nearby café to call for help. Meanwhile, Jeff is able to fix the car and make his way to the café, but Amy isn't there. He tracks down the trucker ― who tells the police he's never seen Jeff or his wife before. Jeff then begins a desperate, frenzied search for Amy.
Aglaé, a young factory worker, has only one focus in life: her job at a car crash test site. When she learns that the factory is going to be relocated abroad, she accepts, to everyone's surprise, to go to India in order to hold on to her job. Accompanied by two colleagues, she sets out on a perilous road trip to the other side of the world.
The murderous, backwoods Firefly family take to the road to escape the vengeful Sheriff Wydell, who is not afraid of being as ruthless as his target.
Lincoln Hawk a hard-luck big-rig trucker takes us under the glaring Las Vegas lights for all the boisterous action of the World Armwrestling Championship. Relying on wits and willpower, Hawk tries to rebuild his life by capturing the first-place prize money, and the love of the son he abandoned years earlier into the keeping of his rich, ruthless father-in-law.
Brash, loudmouthed and opportunistic, Kikujiro is the unlikely companion for Masao who is determined to see the mother he has never met. The two begin a series of adventures which soon turns out to be a whimsical journey of laughter and tears with a wide array of surprises and unique characters along the way.
Married small-time crooks Lou-Jean and Clovis Poplin lose their baby to the state of Texas and resolve to do whatever it takes to get him back. Lou-Jean gets Clovis out of jail, and the two steal their son from his foster home, in addition to taking a highway patrolman hostage. As a massive dragnet starts to pursue them across Texas, the couple become unlikely folk heroes and even start to bond with the captive policeman.
Lloyd and Harry are two men whose stupidity is really indescribable. When Mary, a beautiful woman, loses an important suitcase with money before she leaves for Aspen, the two friends (who have found the suitcase) decide to return it to her. After some "adventures" they finally get to Aspen where, using the lost money they live it up and fight for Mary's heart.
A naive Canadian barber who knows US popular culture inside and out meets a flamboyant roadie who needs someone to drive her and her "brother's" corpse from Thunder Bay, Ontario to New Orleans. Chaos ensues after the barber agrees to drive her, the corpse, and the drugs stashed within all the way.
Once called "Father Frank" for his efforts to rescue lives, Frank Pierce sees the ghosts of those he failed to save around every turn. He has tried everything he can to get fired, calling in sick, delaying taking calls where he might have to face one more victim he couldn't help, yet cannot quit the job on his own.
When Erik Stifler realizes that he's the only Stifler family member who might graduate high school a virgin, he decides to live up to his legacy. After some well-meaning advice from Jim's dad, Erik's ready to take his chances at the annual and infamous Naked Mile race, where his devoted friends and some uninhibited sorority girls will create the most outrageous weekend ever.
Still grieving after the murder of her boyfriend, hairdresser Justice writes poetry to deal with the pain of her loss. Unable to get to Oakland to attend a convention because of her broken-down car, Justice gets a lift with her friend, Iesha, and Iesha's postal worker boyfriend, Chicago. Along for the ride is Chicago's co-worker, Lucky, to whom Justice grows close after some initial problems. But is she ready to open her heart again?
With the help of an irreverent young sidekick, a bank robber gets his old gang back together to organise a daring new heist.
Trucker Rubber Duck and his buddies Pig Pen, Widow Woman and Spider Mike use their CB radios to warn one another of the presence of cops. But conniving Sheriff Wallace is hip to the truckers' tactics, and begins tricking the drivers through his own CB broadcasts. Facing constant harassment from the law, Rubber Duck and his pals use their radios to coordinate a vast convoy and rule the road.
Corporate billionaire Edward Cole and working class mechanic Carter Chambers are worlds apart. At a crossroads in their lives, they share a hospital room and discover they have two things in common: a desire to spend the time they have left doing everything they ever wanted to do and an unrealized need to come to terms with who they are. Together they embark on the road trip of a lifetime, becoming friends along the way and learning to live life to the fullest, with insight and humor.
After breaking up with her girlfriend, a nightclub singer, Jane, answers a personal ad from Robin, a real estate agent with AIDS, seeking a cross-country travel partner. On their journey from New York City to Los Angeles, the two stop by Pittsburgh to pick up Jane's friend Holly, who is trying to escape an abusive relationship. With three distinct personalities, the women must overcome their differences to help one another.
A road trip to Los Angeles inadvertently leads a young man from Wyoming into a wild maze of psychotic hit-men, racy women, jewel thieves and a salsa band.
Gib, a beer-guzzling slob, and Alison, an uptight Ivy-Leaguer, are an unlikely duo stuck together on a cross-country trip during Christmas break. At first they get on each other's nerves but, as time passes, they find their divergent natures complement each other. Now they need to realize what they've already found before it's too late.
A bounty hunter pursues a former Mafia accountant who is also being chased by a rival bounty hunter, the F.B.I., and his old mob boss after jumping bail.