An anthology of five macabre short stories about hungry ghosts, comatose brain dead, a group of bright-eyed actors, an unscrupulous car salesman, and careless backpack tourists.
After FBI agent Frank Lacrosse believes his son was kidnapped by a notorious serial killer, he travels to Amarillo, Texas, where he believes the murderer is in hiding. Although officially taken off the case because of its personal significance to him, Frank continues to pursue the killer, causing concern for local sheriff Buck Olmstead. When another victim pops up at a nearby car garage, Frank knows that he is as close as he'll ever be to tracking down the elusive killer.
Following the arrest of her mother, Ramona, young Vanessa Lutz decides to go in search of her estranged grandmother. On the way, she is given a ride by school counselor Bob Wolverton. During the journey, Lutz begins to realize that Bob is the notorious I-5 Killer and manages to escape by shooting him several times. Wounded but still very much alive, Bob pursues Lutz across the state in this modern retelling of Little Red Riding Hood.
Kowalski works for a car delivery service, and takes delivery of a 1970 Dodge Challenger to drive from Colorado to San Francisco. Shortly after pickup, he takes a bet to get the car there in less than 15 hours.
Charles and Meg, a young couple whose relationship is currently experiencing some distress, go on vacation in Paestum hoping to mend their problems. But along the way they pick up an aggressive and unscrupulous hitchhiker.
A young man is in a race against time as he searches for a cure after becoming infected with a virus that will eventually turn him into a blood-sucking vampire.
Zia, distraught over breaking up with his girlfriend, decides to end it all. Unfortunately, he discovers that there is no real ending, only a run-down afterlife that is strikingly similar to his old one, just a bit worse. Discovering that his ex-girlfriend has also "offed" herself, he sets out on a road trip to find her.
A high school senior drives cross-country with his best friends to hook up with a babe he met online.
Wildcatter Johnny Maverick and his pal go to a town in oil country offering $25,000 to the person who brings in the first well. They find oil on the outskirts but have to sell a share to a promoter who hires Johnny's old enemy.
Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
Through a series of misunderstandings, Alvin, Simon and Theodore come to believe that Dave is going to propose to his new girlfriend in New York City - and dump them. They have three days to get to him and stop the proposal.
Matt, with the assistance of his new friend Riley, is moving out to Los Angeles California to fulfill his dream of making movies. Everything is off to a good start! That is until Matt's childhood best friend Chaps decides to crash the road trip and invite himself along. When old friends don't mix well with new friends, jealousy enters the picture. And if that wasn't enough to put a damper on the road trip, a menacing hitchhiker turns their world upside down leading to a maddening chase that spins wildly out of control.
Joe and Paul Fabrini are Wildcat, or independent, truck drivers who have their own small one-truck business. The Fabrini boys constantly battle distributors, rivals and loan collectors, while trying to make a success of their transport company.
One evening, Hammer gives a ride to Christina, an attractive hitchhiker on a lonely country road, who has escaped from the nearby lunatic asylum. Thugs waylay them and force his car to crash. When Hammer returns to semi-consciousness, he hears Christina being tortured until she dies. Hammer, both for vengeance and in hopes that "something big" is behind it all, decides to pursue the case.
Rick Robinson, a law intern, is scheduled to take the bar exam in just four days. Anxious to score points with his boss Mr. McAllister, Rick unwisely agrees to help the man move. The next day, Rick finds himself in a moving van from Miami to Los Angeles, accompanied by McAllister's spoiled niece and her pet pig.
A young woman stumbles into a nightmare land of hijacking and humiliation while driving cross-country from California to New York.
Three macabre tales from the latest issue of a boy's favorite comic book, dealing with a vengeful wooden Native American, a monstrous blob in a lake, and an undying hitchhiker.
A drop-out from upper-class America picks up work along the way on oil-rigs when his life isn't spent in a squalid succession of bars, motels, and other points of interest.
On their way to an afternoon on the lake, husband and wife Andrzej and Krystyna nearly run over a young hitchhiker. Inviting the young man onto the boat with them, Andrzej begins to subtly torment him; the hitchhiker responds by making overtures toward Krystyna. When the hitchhiker is accidentally knocked overboard, the husband's panic results in unexpected consequences.
Chasing a memory, Alex is determined to drive cross-country to Melbourne. Planning on having just the highway for company, he reluctantly picks up a hitchhiker running from something with as much determination as Alex is running to something.