Elizabeth has just been through a particularly nasty breakup, and now she's ready to leave her friends and memories behind as she chases her dreams across the country. In order to support herself on her journey, Elizabeth picks up a series of waitress jobs along the way. As Elizabeth crosses paths with a series of lost souls whose yearnings are even greater than her own, their emotional turmoil ultimately helps her gain a greater understanding of her own problems...
On their cross-country drive, a married couple, Jeff and Amy Taylor, experience car trouble after their SUV breaks down. Stranded in the New Mexico desert, the two catch a break when a passing truck driver offers Amy a ride to a nearby café to call for help. Meanwhile, Jeff is able to fix the car and make his way to the café, but Amy isn't there. He tracks down the trucker ― who tells the police he's never seen Jeff or his wife before. Jeff then begins a desperate, frenzied search for Amy.
Focuses on three very different siblings, all searching for happiness. Hans-Jörg is a sex addicted librarian, who is interested in young students. Werner is a successful politician with a dysfunctional family. Agnes, a trans woman, works as a table dancer in a night club. The three brothers just have one thing in common: their longing for a happy life.
Louise, who has just written a novel, comes to Paris to meet with a potential publisher. While in the city, she stays with her older sister, Martine, who in many ways is the exact opposite of Louise: she lives in a fashionable neighborhood, is cold to others, and has snobby friends, while Louise lives in a small town and is thoroughly unpretentious. Louise's apparent happiness -- and similarities to their mother -- gradually gets on Martine's nerves.
A Jewish woman named Jettel Redlich flees Nazi Germany with her daughter Regina, to join her husband, Walter, on a farm in Kenya. At first, Jettel refuses to adjust to her new circumstances, bringing with her a set of china dishes and an evening gown. While Regina adapts readily to this new world, forming a strong bond with her father's cook, an African named Owuor.
The murderous, backwoods Firefly family take to the road to escape the vengeful Sheriff Wydell, who is not afraid of being as ruthless as his target.
Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.
Aspiring Florida defense lawyer Kevin Lomax accepts a job at a New York law firm. With the stakes getting higher every case, Kevin quickly learns that his boss has something far more evil planned.
Marie, who works as a successful door-to-door encyclopedia salesperson, has been married to her husband Francois for 12 years and has a two-year-old son. Though she is relatively content with her life, she feels something is wanting. Enter 50-year old African-American Bill. Initially she is annoyed by his insouciance, but she finds that she is irresistibly attracted to him. Soon the two are in the midst of sordid illicit affair. She knows little about her new lover, and he seems uninterested in learning about her, but the long sessions of lovemaking are something else entirely. Feeling out of control, Marie is increasingly repelled by her own actions. Psychologically, she struggles to reconcile her torrid encounters with Bill and mundane domestic chores such as bathing her son. Moreover, she finds herself incapable of hiding her adulterous behavior, rather she comes home with scratches and hickeys all over her body, to the devastation Francois.
Chasing a memory, Alex is determined to drive cross-country to Melbourne. Planning on having just the highway for company, he reluctantly picks up a hitchhiker running from something with as much determination as Alex is running to something.
Lincoln Hawk a hard-luck big-rig trucker takes us under the glaring Las Vegas lights for all the boisterous action of the World Armwrestling Championship. Relying on wits and willpower, Hawk tries to rebuild his life by capturing the first-place prize money, and the love of the son he abandoned years earlier into the keeping of his rich, ruthless father-in-law.
After a meet-cute in a bar, Dawn and Micah's road trip to Portland turns into a nightmare when they're hunted by an infamous serial killer known as the Mechanic Maniac.
Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman and Orlean's book become strangely intertwined as each one's search for passion collides with the other's.
Ray Kinsella is an Iowa farmer who hears a mysterious voice telling him to turn his cornfield into a baseball diamond. He does, but the voice's directions don't stop -- even after the spirits of deceased ballplayers turn up to play.
A quintet of cabbies in five cities and their remarkable fares on the same eventful night.
Retired farmer and widower Alvin Straight learns one day that his distant brother Lyle has suffered a stroke and may not recover. Alvin is determined to make things right with Lyle while he still can, but his brother lives in Wisconsin, while Alvin is stuck in Iowa with no car and no driver's license. He then has the idea of making the trip on his old lawnmower, thus beginning a picturesque and at times deeply spiritual odyssey.
When Gelsomina, a naïve young woman, is purchased from her impoverished mother by brutish circus strongman Zampanò to be his wife and partner, she loyally endures her husband's coldness and abuse as they travel the Italian countryside performing together. Soon Zampanò must deal with his jealousy and conflicted feelings about Gelsomina when she finds a kindred spirit in Il Matto, the carefree circus fool, and contemplates leaving Zampanò.
Christian is a presenter at a small radio station. His wife Katrin directs traffic in a car park. Both are friends with Uwe, who runs a fast food kiosk, and Ellen, who works in a perfume shop. Their four lives are stuck in a rut. Until the day Chris and Ellen sleep together and upset the balance of the two couples...
Disciplined Italian composer Antonio Salieri becomes consumed by jealousy and resentment towards the hedonistic and remarkably talented young Salzburger composer Wolfgang Amadeus Mozart.
When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.