The sheriff, Dan Beckham, and his deputy, Bud Cameron, are posting signs offering a reward for the capture of Cheyenne Harry, accused of holding up a Wells Fargo shipment. Shortly after they have tacked the sign to a tree Cheyenne Harry removes it.
A serio-comic tale shows wherein the East and the West strangely mingle despite Kipling's declaration that: "Never the twain shall meet."
With a price upon his head. Texas Pete takes to the open country.
The new foreman falls in love with the ranchman's daughter, and notes with jealousy her joy over a letter which her father receives.
Out of the talk at the Sportsmen's Club arises a wager between the globe-trotter and his friend, who bets that he will not be able, within a fixed time, to find his way out of an isolated mountain location to which he will lead him.
Helen Martin takes her father's place when he is too ill to carry out his duties as Sheriff, and followed by Jim Grey, tracks down Blackie Wells, notorious 'bad man,' who has shot up a town. The trail leads over prairie and woodland, ending when Helen assumes the part of a dancing girl in the Last Chance saloon and learns the hiding place of Blackie and his associates.
Claim jumper Dave Marco and his boss Earl Foster, a crooked investment broker, hire chemist Ralph Brandon to falsify papers that a certain worthless mine is valuable then convince Ralph's mother to invest all her money in the mine. Ralph’s sister Holly meets Jack Mason, whose mine is actually valuable though not yet profitable, and they fall for each other. Once Mrs. Brandon finds out she has been duped, though forced into silence by the threat of having Ralph’s malfeasance exposed, and Marco attempts to jump Jack’s claim events come to a head until the happy conclusion.
A drifter hobo is falsely accused of killing a saloon owner
Dolly Mainard, en route to her father, a major at Fort Blaine, is escorted through dangerous Sioux territory by a cavalry detachment and Army scout Jim Cardigan. When Captain Blackwell offends some braves of Chief Gray Wolf's tribe, Jim is sent ahead to the Indian camp to ask for peace. Imprisoned by the Indians, he sends a message to Blackwell not to advance; Donlin, a renegade scout, tears the note in such a way that the message is distorted, and the entire force is killed. When Jim escapes, he is accused of treason by Blackwell, court-martialed, and sentenced to death; however, he escapes and rescues Dolly, her father, and Blackwell from Donlin's band of renegades. Jim discovers the missing portion of the note in Donlin's hat, proving his innocence. Dolly remains to become his wife.
J. Wesley Pringle and S. S. Thorpe are running against each other for sheriff. Unscrupulous Thorpe has his gang kidnap Pringle to prevent his win but Georgie Hibler, the daughter of Pringle's biggest supporter and her good friend, Fite, whom Pringle had saved from suicide, team up to saves him from the gang. Pringle wins the election and the girl!
Gracia, a half-breed Indian girl, plots with Cons Saunders to steal cattle from Blake because he is oblivious to her charms. With his stock gone, he cannot repay the money he owes his Uncle Benedict, and when Benedict is murdered, Blake is suspected. Because Blake has taken care of Saunders (Cons's father) for the many years he has been without the use of his legs, the latter is finally conscience-stricken and confesses to the crime, thus freeing Blake to marry Diana.
Tiger Thompson promises a dying train robber to mind his innocent daughter and return the stolen loot. Along the way, Thompson is attacked by the dead man's gang but manages to reach the law (and the girl) in one piece and with the stolen money intact.
A boy's father is an unjustly accused fugitive, and the boy's scheming uncle plots to become the youngster's guardian and take over the family fortune.
The only key to a young woman's fortune lies in a marking on the leg of a horse called The Ghost of the Gauchos. But the woman's guardian, her uncle, plots to steal her wealth.
Bruce McLeod returns from the goldfields to find that his wife has left home with another man, taking their child. After the death of the mother, the child is adopted by Cherie, a local dancehall girl ostracized by the community. Cullum, a gambler who earlier seduced Mrs. McLeod, drifts into the town, and failing to win Cherie, he swears vengeance. McLeod, seeking the man who wrecked his home, falls in love with Cherie but scorns her when he discovers that she is a dancer. Ultimately, the child identifies Cullum as the gambler who lured Mrs. McLeod from her home. In the ensuing fight, Cullum is shot by a halfbreed, and Bruce is happily united with Cherie.
Major Carter, owner of the Sunset mines, reads of a reward offered for Cheyenne Harry if captured. The butler gives him a telegram telling of the flooding of several shafts in his mine. He is soon on the way to the mine in his car. Ruth, his daughter, follows in her roadster.
John Gregg and his daughter Mary, on their way to Burro Springs, a boom mining town, lose their way and stumble into "Jawbone," a dilapidated town. Here they meet Mike Hernandez, a good-looking bad man. Mary, thinking Mike a gentleman, takes a liking to him. "Cheyenne" Harry, a homely looking good man, comes to Jawbone and Mary believes him to be a weak character. He becomes fascinated with her. Gregg hires Mike Hernandez to guide him to Burro Springs, displaying his small store of gold when paying Hernandez. Later, Gregg and his party become lost in the desert, and run out of water.
Professor Duane, an ethnologist, and his assistant, Roscoe Harding, plan a journey into the wilds of Hindustan. Harding is in love with Lydia, the daughter of Professor Duane, and they are engaged to be married. Lieutenant Tavish, a British army officer, is attracted to Lydia and plans to take her away from Harding by fair means or foul.
Seeker Dean has found the gold he has been looking for for 15 years. Heading for the Government office, Boone Jackson kills him. Kickabout finds a cryptogram as to the gold's location and Sergeant Kinkaid solves the puzzle. But Jackson learns of the gold's location and to get it, he sets out to dynamite the dam that would flood the entire communuty.
Billy Milford, Harvard graduate, goes west to seek his fortune. In Addertown he secures a position as stationmaster of the L. & R. Railroad, but is forced out because of his drinking habits. He accidentally meets Gunhild, an emigrant Norwegian girl, as she arrives in Addertown to take up her home with Jan Hagsberg, the town's saloonkeeper. Seeking revenge on the railroad, Milford joins Jim Dorsey in a scheme to hold up the road's paymaster on his way to pay the employees of the company's mine.