Hired ranch hand Tex Smith is smitten with Lucy Blake, who lives in the cattle settlement of Marco. Meanwhile, Indian chief Brave Bear despises the encroachment of white people and conspires with Sam Hardman to steal the town's cattle during a rodeo.
Ranger Job "Blue Streak" McCoy helps a miner and his pretty young daughter who are trying to protect their valuable mine from a gang leader who wants to take it.
Outlaw Jesse James is rumored to be the 'fastest gun in the West'. An eager recruit into James' notorious gang, Robert Ford eventually grows jealous of the famed outlaw and, when Robert and his brother sense an opportunity to kill James, their murderous action elevates their target to near mythical status.
As a baby, John Ermine is stolen from a wagon train by the Crow Indians and is adopted by Chief Fire Bear. John grows to manhood, ignorant that he is a white man until his parentage is disclosed to him by Crooked Bear, a white hermit who is on friendly terms with the Crows. Crooked Bear teaches John the language and customs of the white man's civilization, impressing upon him that it is his sacred responsibility to keep peace between the white men and the Indians.
Drifters Tom Williams and Joe Morgan have a chance meeting with the sheriff's daughter and learn that her brother Jim is being held prisoner in Line Hollow by Wolf, who aspires to be the next sheriff. They aid the sheriff in finding the outlaw gang and rescuing Jim. Tom decides to stop drifting and stay near the sheriff's daughter.
Dr. Frankenstein's Granddaughter Maria, and her brother assistant Rudolph, moved to the old west because the lightning storms there are more frequent and intense, which allows them to work on the experiments of their grandfather. But the experiments are failing and Rudolph's been secretly killing the corpses afterwards. Meanwhile, the Lopez family leaves the town because of the evil going on there
For Nita Valyez, who is half-Spanish and half-Irish, Carlos represents potential violence and danger, two things to which she is both attracted and repelled. In contrast, she has only a passing interest in Big Jim, the town's honest, good-hearted sheriff. Then, after Carlos kills a faro dealer, he forces Nita to make an escape with him.
Our hero is mistaken for a bandit. Al's girl Nancy at first believes him to be guilty, but he manage to convince her that the real bandit is McDonald.
While in Europe, Chaddie Green, a society girl, discovers that she has been left penniless. She returns to the United States and meets Duncan MacKail, who is equally broke though he owns grainland in the West. Duncan and Chaddie are married and go west to homestead. Duncan hires Ollie, a Swedish caretaker, who frightens Chaddie. When business takes Duncan away, Chaddie goes to take care of Percy Woodhouse, an Englishman who has become ill at his place fifteen miles away. Her horse runs away, and she is forced to spend the night there. She sleeps under a wagon, but Duncan is nevertheless angry and jealous.
An outlaw decides to hang up his guns and lead the "straight" life. His foster son falls for the daughter of a wealthy estate owner. The crooked manager of the estate wants the girl for himself--so he can control the estate when the father dies--and tells the father that the boy is an outlaw's son.
Miner Dan Stuyvesant finally strikes it rich, but on his way to report his claim, he is shot. When Jack Dedlow, the head of a gang of outlaws, hears this news, he rides to Stuyvesant's cabin intending to secure the claim for himself. There the outlaws find Stuyvesant's daughter Hilda, the sweetheart of Tom Flynn, and are about to draw cards for her when Dago Sam pulls out his guns and spirits her out the door. Because Tom is his only friend, Sam determines to protect Hilda from the gang, but when Tom suspiciously questions his intentions toward Hilda, Sam decides to live up to the town's poor opinion of him.
The Northwest Mounties are after Cheyenne Harry for the murder of an Indian boy, and the only witness to the crime is a priest - who can't tell what he saw because the real killer, Black Michael, has confessed to him.
Secret Serviceman Allen takes a job at Bart Stevens' mine in order to find evidence proving that Stevens is a mail robber named Smoke Gublen. He does - but by then, he is in love with the man's sister - and to make things harder, Stevens saves his life...
Bill Drake is a cowpoke who must prove himself innocent of robbing the general store. The real culprit, as our hero detects, is Tom Evans, the weakling son of a local rancher.
Young cowboy Cyclone Jones falls for pretty Sylvia Billings, who with her sheep-rancher father has just come to town. However, his pursuit of Sylvia runs into some roadblocks, mainly the hostility of the local cattle ranchers to "sheepmen" like her father, whose sheep they believe ravage the range and leave it unusable for their cattle to graze on and who are determined to drive the new arrivals out of town.
A beautiful young girl is being forced to marry a crooked real-estate agent by making the girl's brother appear to be a thief. Cowboy Nat Sherwood discovers what's going on and sets out to expose the plot.
When a Midwest town learns that a corrupt railroad baron has captured the deeds to their homesteads without their knowledge, a group of young ranchers join forces to take back what is rightfully theirs. They will become the object of the biggest manhunt in the history of the Old West and, as their fame grows, so will the legend of their leader, a young outlaw by the name of Jesse James.
The gangs of Jesse James and Cole Younger join forces to rob the First National Bank in Northfield, Minnesota, but things do not go as planned.
Vic Stanley, a wandering cowboy, is found by Clint Taggart and his daughter, Amy, after he has escaped from a band of rustlers. Upon recovering his sight from a desert sandstorm, he sees and falls in love with Amy and becomes resolute in his decision to uncover the identity of the rustlers and particularly their leader, "The Eagle." Though blind during his capture, he nevertheless recognizes the voice of The Eagle in McElroy, a leading banker. After another escape from the gang, Vic manages to save Taggart and Amy from The Eagle's sticky clutches, exposes their operation, and proceeds on course with Amy.
A US Army officer is sent undercover into the hills of Mexico's Baja California region to find and bring down the madman Crando and his group of crazed followers, who are setting up their own criminal empire spreading from Mexico into the United States.