The period is 1876; trains of settlers are moving westward. It is the time of pioneers and prairie schooners. Dan is leading one wagon train and his party fall in with another led by a stalwart Indian, Mahomena. They proceed together. Amongst the latter party is a young girl, Eunice, and she and Dan are immediately attracted to each other
Bob arrives looking for the killer of his uncle. When the Sheriff chases him and his partner Rusty, Reno thinks they are the men he is looking for and takes them into his gang. There Bob finds his uncle's gun and knows he has found the right gang. However he realizes the gang has an unknown leader and he sets out to find him.
When Tex is brought in to fight in a range war between the cowmen and the nesters, he meets his old outlaw boss Lassiter. He learns Lassiter is behind the feud when Lassiter asks him to join up with his gang. Tex refuses and instead sets out to stop the feud but no one will believe him that Lassiter is responsible.
A man escapes from prison, then joins up with a gang of stage robbers while at the same time working as a deputy in a distant town, hoping to ultimately find the outlaw who killed his father during a robbery years ago.
Trouble starts when Bill Larkins and his two sons move in with his brother Joe. They start rustling cattle and then kill Rod's father with Joe's gun. The Sheriff and Rod think they did it and are after proof.
Dyer is buying ranches and then retrieving his check by having his gang kill the owner. Bob Worth arrives just as Buck Morton is killed and gets blamed for the murder. Fleeing from the Sheriff, Bob teams up with the Mexican outlaw Golinda. Having seen Dyer pay off his men, he has a plan to trap him and Golinda is just the man he needs to make it work.
A cattleman's association hires a range detective to track down and capture a notorious rustler known as El Lobo.
Bill Carson arrives and tells Cash Horton that his supposedly worthless mine contains valuable tungsten. Duke learns of the mine's value and tries to have them both killed. Failing, he has the Sheriff arrest Bill for murder. Unknown to Bill and the Sheriff, the victim is alive and well.
Perrin is a cowboy who comes to the aid of local Indians being swindled out of their gold. He signs on as a ranch foreman, but learns the ranch is the home of the crooks.
Perrin and his partner get paid a big sum of money at the end of their cattle drive. Shortly thereafter, the partner is found with a knife in his back and Perrin is blamed for the murder.
A cowboy comes to the aid of a lady rancher threatened by Mexican bandits who believe there is a treasure buried on her land.
Hud Dixon returns to his hometown when his brother is killed by a lynch mob.
On a trip to the beach, a teenage girl named Tobe meets a charismatic stranger named Harlan, who dresses like a cowboy and claims to be a former ranch hand. The pair feel an instant attraction and begin a relationship, but her father, a lawman, is suspicious of her lover.
Before the U.S. Civil War rebel leader Luke Darcy sees himself as leader of a new independent Republic of Kansas but the military governor sends an ex-raider to capture Darcy.
Half-breed Keoma returns to his border hometown after service in the Civil War and finds it under the control of Caldwell, an ex-Confederate raider, and his vicious gang of thugs. To make matters worse, Keoma's three half-brothers have joined forces with Caldwell, and make it painfully clear that his return is an unwelcome one. Determined to break Caldwell and his brothers' grip on the town, Keoma partners with his father's former ranch hand to exact violent revenge.
Having fled to Mexico from the U.S. many years ago for killing his father's murderer, Martin Brady travels to Texas to broker an arms deal for his Mexican boss, strongman Governor Cipriano Castro. Brady breaks a leg and while recuperating in Texas the gun shipment is stolen. Complicating matters further the wife of local army major Colton has designs on him, and the local Texas Ranger captain makes him a generous offer to come back to the states and join his outfit. After killing a man in self-defense, Brady slips back over the border and confronts Castro who is not only unhappy that Brady has lost his gun shipment but is about to join forces with Colton to battle the local raiding Apache Indians.
The neighbors of a frontier family turn on them when it is suspected that their beloved adopted daughter was stolen from the Kiowa tribe.
Cole Thornton, a gunfighter for hire, joins forces with an old friend, Sheriff J.P. Harrah. Together with a fighter and a gambler, they help a rancher and his family fight a rival rancher that is trying to steal their water.
Dan and Tennessee are successful gold miners. Ace Brady learns of their success and sends Fox to rob them. During the robbery Fox shoots Tennessee and Ace arrives to arrest Dan for the murder. Dan escapes but is now a wanted man.
The epic story of the opening of the Canadian West and the drought that brought the Depression in the thirties. This is the saga of a family who left eastern Canada to stake their future in the Prairies.